Tuberculosis associates with a wide spectrum of disease outcomes. The Beijing (Bj) lineage of Mycobacterium tuberculosis (Mtb) is suggested to be more virulent than other Mtb lineages and prone to elicit non-protective immune responses. However, highly heterogeneous immune responses were reported upon infection of innate immune cells with Bj strains or stimulation with their glycolipids. Using both in vitro and in vivo mouse models of infection, we here report that the molecular mechanism for this heterogeneity may be related to distinct TLR activations. Among this Mtb lineage, we found strains that preferentially activate TLR2, and others that also activate TLR4. Recognition of Mtb strains by TLR4 resulted in a distinct cytokine profile in...
In 2015, there were an estimated 10.4 million new cases of tuberculosis (TB) globally, making it one...
One of the most widespread clades of Mycobacterium tuberculosis worldwide, the Beijing genotype fami...
Mycobacterium tuberculosis (Mtb) is the etiological agent of the disease tuberculosis (TB), and is t...
Tuberculosis associates with a wide spectrum of disease outcomes. The Beijing (Bj) lineage of Mycoba...
<div><p>Tuberculosis associates with a wide spectrum of disease outcomes. The Beijing (Bj) lineage o...
Genetic diversity of Mycobacterium tuberculosis affects immune responses and clinical outcomes of tu...
BACKGROUND: As a species, Mycobacterium tuberculosis is more diverse than previously thought. In par...
Toll-like receptors (TLRs) play critical roles in the innate recognition of Mycobacterium tuberculos...
AbstractIntroductionTuberculosis (TB) is considered a major worldwide health problem with 10million ...
Introduction: Tuberculosis is still a leading cause of bacterial infection worldwide, with an estima...
The role of Toll-like receptors (TLR) and MyD88 for immune responses to Mycobacterium tuberculosis (...
Substantial differences exist in virulence among Mycobacterium tuberculosis strains in preclinical T...
Genetic diversity of Mycobacterium tuberculosis affects immune responses and clinical outcomes of tu...
Genetic diversity of Mycobacterium tuberculosis affects immune responses and clinical outcomes of tu...
Genetic diversity of Mycobacterium tuberculosis affects immune responses and clinical outcomes of tu...
In 2015, there were an estimated 10.4 million new cases of tuberculosis (TB) globally, making it one...
One of the most widespread clades of Mycobacterium tuberculosis worldwide, the Beijing genotype fami...
Mycobacterium tuberculosis (Mtb) is the etiological agent of the disease tuberculosis (TB), and is t...
Tuberculosis associates with a wide spectrum of disease outcomes. The Beijing (Bj) lineage of Mycoba...
<div><p>Tuberculosis associates with a wide spectrum of disease outcomes. The Beijing (Bj) lineage o...
Genetic diversity of Mycobacterium tuberculosis affects immune responses and clinical outcomes of tu...
BACKGROUND: As a species, Mycobacterium tuberculosis is more diverse than previously thought. In par...
Toll-like receptors (TLRs) play critical roles in the innate recognition of Mycobacterium tuberculos...
AbstractIntroductionTuberculosis (TB) is considered a major worldwide health problem with 10million ...
Introduction: Tuberculosis is still a leading cause of bacterial infection worldwide, with an estima...
The role of Toll-like receptors (TLR) and MyD88 for immune responses to Mycobacterium tuberculosis (...
Substantial differences exist in virulence among Mycobacterium tuberculosis strains in preclinical T...
Genetic diversity of Mycobacterium tuberculosis affects immune responses and clinical outcomes of tu...
Genetic diversity of Mycobacterium tuberculosis affects immune responses and clinical outcomes of tu...
Genetic diversity of Mycobacterium tuberculosis affects immune responses and clinical outcomes of tu...
In 2015, there were an estimated 10.4 million new cases of tuberculosis (TB) globally, making it one...
One of the most widespread clades of Mycobacterium tuberculosis worldwide, the Beijing genotype fami...
Mycobacterium tuberculosis (Mtb) is the etiological agent of the disease tuberculosis (TB), and is t...