Cancer

Background:Hodgkin lymphoma (HL) is a treatable tumor affecting children, adolescents, and young adults (AYA; 15 \u2013 39 years). Population-based studies report worse survival in non-White children and AYAs but have limited data on individual therapeutic exposures. We examined overall and HL-specific survival in a population-based cohort of patients while adjusting for sociodemographic factors and treatment.Methods:Data for 4,807 patients <40 years with HL (2007 \u2013 2017) were obtained from the California Cancer Registry. Individual treatment information was extracted from text fields; chemotherapy regimens were defined by standard approaches for pediatric and adult HL. Multivariable Cox models examined the influence of patient and treatment factors on survival.Results:At median follow-up of 4.4 years, 95% of patients were alive. Chemotherapy differed by age, with 70% of 22\u201339 vs. 41% of <22-year-olds receiving ABVD (p<0.001). In multivariable models, older (22 \u2013 39 vs. <22y; hazard ratio (HR): 1.52, 95% confidence interval (CI): 1.10, 2.09), Black (vs. White; HR: 1.90, 95%CI 1.25, 2.88) and Hispanic (HR: 1.48, 95%CI: 1.07, 2.03) patients experienced worse survival; among those