Parkinson’s disease (PD), first described by James Parkinson in 1817, is a chronic, progressive neurodegenerative disorder. The pathologic hallmark is a deterioration of the substantia nigra of yet unknown causes, resulting in a deficiency of dopamine, an important neurotransmitter for the basal ganglia circuit and the presence of cytoplasmic eosinophilic inclusions named Lewy bodies, in which α-synuclein is the major constituent. Recent work implicates abnormal protein accumulation, protein phosphorylation, mitochondrial dysfunction and oxidative stress as common pathways implicated in PD pathogenesis. Polyphenolic compounds are commonly found in both edible an...
Aggregation of alpha-synuclein (alpha-SN) is a key pathogenic event in Parkinson's disease (PD) lead...
Parkinson�s disease is the second most common neurodegenerative disorder with selective and progre...
Parkinson disease is characterized by a progressive and selective loss of dopaminergic neurons in th...
Parkinson’s disease (PD) is a neurodegenerative disorder with high prevalence and is ch...
Parkinson’s disease (PD) is a neurodegenerative disorder which disrupts the lives of 5 million peopl...
Tese de mestrado, Neurociências, Faculdade de Medicina, Universidade de Lisboa, 2010α-Synuclein (αSy...
In this study, cell experiments were conducted to investigate the effects of extracts on cell viabil...
Parkinson’s disease (PD) is the second most common neurodegenerative disorder. However, therap...
: Parkinson's disease (PD) is second-most common disabling neurological disorder worldwide, and unfo...
We acknowledge Rita Ramos for support with qRT-PCR and Regina Menezes for the selection of primers; ...
Parkinson’s disease (PD) is the second most common neurodegenerative disease, and affects 1-2% of t...
Parkinson's disease (PD) is an age-related neurodegenerative disorder characterized by the slow and ...
α-Synuclein aggregation and fibrillation are closely associated with the formation of Lewy bodies in...
Parkinson's disease is a chronic, debilitating neurodegenerative movement disorder characterized by ...
Both genetic and environmental factors are important in the pathogenesis of Parkinson′s disease. As ...
Aggregation of alpha-synuclein (alpha-SN) is a key pathogenic event in Parkinson's disease (PD) lead...
Parkinson�s disease is the second most common neurodegenerative disorder with selective and progre...
Parkinson disease is characterized by a progressive and selective loss of dopaminergic neurons in th...
Parkinson’s disease (PD) is a neurodegenerative disorder with high prevalence and is ch...
Parkinson’s disease (PD) is a neurodegenerative disorder which disrupts the lives of 5 million peopl...
Tese de mestrado, Neurociências, Faculdade de Medicina, Universidade de Lisboa, 2010α-Synuclein (αSy...
In this study, cell experiments were conducted to investigate the effects of extracts on cell viabil...
Parkinson’s disease (PD) is the second most common neurodegenerative disorder. However, therap...
: Parkinson's disease (PD) is second-most common disabling neurological disorder worldwide, and unfo...
We acknowledge Rita Ramos for support with qRT-PCR and Regina Menezes for the selection of primers; ...
Parkinson’s disease (PD) is the second most common neurodegenerative disease, and affects 1-2% of t...
Parkinson's disease (PD) is an age-related neurodegenerative disorder characterized by the slow and ...
α-Synuclein aggregation and fibrillation are closely associated with the formation of Lewy bodies in...
Parkinson's disease is a chronic, debilitating neurodegenerative movement disorder characterized by ...
Both genetic and environmental factors are important in the pathogenesis of Parkinson′s disease. As ...
Aggregation of alpha-synuclein (alpha-SN) is a key pathogenic event in Parkinson's disease (PD) lead...
Parkinson�s disease is the second most common neurodegenerative disorder with selective and progre...
Parkinson disease is characterized by a progressive and selective loss of dopaminergic neurons in th...