We investigated the antioxidant properties of two new diarylamines from organic synthesis (MJQ1 and MJQ2), whose basic structure is similar to others, with reported antioxidant capacity, assessed by chemical tests, and biological activity against microorganisms. In this study we induced lipid peroxidation, in isolated rat liver mitochondria with ADP/Fe2+, and the diarylamine effects were examined by oxygen consumption and by TBARS method. The anti-peroxidative effect was maximal for MJQ1 at 50 nM (higher than the one reported for trolox) and for MJQ2 at 60 μM. At these same concentrations none of them depressed the transmembrane potential (ΔΨ) developed by mitochondria, neither the RCR nor the ADP/O ratio values. For 2-fold these concent...
abstract: Mitochondria are crucial intracellular organelles which play a pivotal role in providing e...
En attente pagination, volume, numéro clé UTPurpose Many phenolics have already been tested for thei...
PF9601N, N-(2-propynyl)-2-(5-benzyloxy-indolyl) methylamine, an monoamine oxidase (MAO) B inhibitor,...
The damaging consequences of free radicals that result from different kinds of oxidative stress have...
http://www.sciencedirect.com/science/article/B6W8G-4TNWGYP-1/2/ba77631bc763067dea4a5c7406e740c
The reducing properties of diarylamines make them very important as antioxidants, especially as rad...
In this study we used new nitrogen compounds obtained by organic synthesis whose structure predicted...
The continuous discovery of new synthetic products with antioxidant activity is of primary importanc...
The imbalance between intracellular reactive oxygen species (ROS) and the cells’ antioxidant defence...
Free radical formation is associated with the normal natural metabolism of aerobic cells. The oxygen...
Background: Mitochondrial dysfunction, oxidative stress and their interplay are core pathological fe...
The antioxidant activity of the aminodi(hetero)arylamines, prepared by C-N coupling of the methyl 3-...
Background: Mitochondrial dysfunction, oxidative stress and their interplay are core pathological fe...
AbstractMitochondrial function and dysfunction contributes to a range of important aspects of biomed...
Oxidative stress has been connected to various forms of cardiovascular diseases. Previously, we hav...
abstract: Mitochondria are crucial intracellular organelles which play a pivotal role in providing e...
En attente pagination, volume, numéro clé UTPurpose Many phenolics have already been tested for thei...
PF9601N, N-(2-propynyl)-2-(5-benzyloxy-indolyl) methylamine, an monoamine oxidase (MAO) B inhibitor,...
The damaging consequences of free radicals that result from different kinds of oxidative stress have...
http://www.sciencedirect.com/science/article/B6W8G-4TNWGYP-1/2/ba77631bc763067dea4a5c7406e740c
The reducing properties of diarylamines make them very important as antioxidants, especially as rad...
In this study we used new nitrogen compounds obtained by organic synthesis whose structure predicted...
The continuous discovery of new synthetic products with antioxidant activity is of primary importanc...
The imbalance between intracellular reactive oxygen species (ROS) and the cells’ antioxidant defence...
Free radical formation is associated with the normal natural metabolism of aerobic cells. The oxygen...
Background: Mitochondrial dysfunction, oxidative stress and their interplay are core pathological fe...
The antioxidant activity of the aminodi(hetero)arylamines, prepared by C-N coupling of the methyl 3-...
Background: Mitochondrial dysfunction, oxidative stress and their interplay are core pathological fe...
AbstractMitochondrial function and dysfunction contributes to a range of important aspects of biomed...
Oxidative stress has been connected to various forms of cardiovascular diseases. Previously, we hav...
abstract: Mitochondria are crucial intracellular organelles which play a pivotal role in providing e...
En attente pagination, volume, numéro clé UTPurpose Many phenolics have already been tested for thei...
PF9601N, N-(2-propynyl)-2-(5-benzyloxy-indolyl) methylamine, an monoamine oxidase (MAO) B inhibitor,...