Synthesis of novel derivatives of a versatile synthon : 4-amino-3-cyanopyrazole

Diazotisation of substituted arylamines followed by reaction with malononitrile gave substituted arylazomalononitriles. Cyclisation of these intermediates with two carbon sources and base gave the corresponding new 4-amino-3-cyanopyrazoles, in moderate yields. In one case the corresponding oxo-pyrazolopyrimidine was prepared.Fundação para a Ciência e Tecnologia - Programa Sócrates