Justification of the composition and technology of combined tablets for the treatment of type II diabetes

The aim. The aim of the work was to establish the feasibility of development, determine the optimal composition and technology, and confirm the pharmacological effectiveness of combined tablets for treating type II diabetes. Materials and methods. Analytical research of the pharmaceutical market of drugs used for the treatment of type II diabetes was carried out using content analysis of official sources of information. The subjects of the study were medicinal products used to treat type II diabetes. A set of physicochemical and technological research methods was used to determine the quality parameters of the tabletting mass and tablets based on them. Results. According to the results of previous studies, similarities in the approaches to the pharmacotherapy of type II diabetes in the countries of Southeast Asia, the Western Pacific region, and Ukraine were established, which became the basis for conducting a market study of drugs with a sugar-lowering effect, namely, based on voglibose, with the aim of further including such drugs in the range of Ukrainian manufacturers. Furthermore, according to the results of physicochemical and technological studies, the composition and rational technology of obtaining tablets were established. Also, pharmacological studies have established that tablets with voglibose and solid dispersion of quercetin significantly prevent the development of glucose metabolism disorders caused by a high-sugar diet. In terms of the expressiveness of the hypocholesterolemic effect of the tablets and their constituent components, they are reliably superior to the comparison drug - metformin. Conclusions. According to the research results, the feasibility and relevance of the development of combined tablets with voglibose and solid dispersion of quercetin have been established. Furthermore, based on the investigated physicochemical and technological indicators, combined tablets' composition and rational technology were developed, and their specific pharmacological activity was prove