Rapamycin rescues mitochondrial dysfunction in cells carrying the m.8344A > G mutation in the mitochondrial tRNALys

Rapamycin inhibited mitochondrial mTOR and blocked radiation-induced bioenergetics switching.

Chung-Ling Lu (711442)
Lili Qin (365085)
Hsin-Chen Liu (546824)
Demet Candas (711443)
Ming Fan (102594)
Jian Jian Li (243325)

March 2015

<p>(A) Western blot of mTOR with mitochondria isolated from MCF-7 cells treated with 20 ng/mL rapamy...

Investigations into pathophysiologic mechanisms and treatment of primary mitochondrial diseases

Siegmund, Stephanie

January 2018

The present work addresses outstanding questions within the field of primary mitochondrial disease b...

Mitochondrial function is affected in GD and FD.

Margarita M. Ivanova (160805)
Erk Changsila (6199691)
Chidima Iaonou (6199694)
Ozlem Goker-Alpan (18201)

January 2019

(A) Effect of rapamycin (RAP) treatment on ATP levels. PBMCs from healthy subjects, GD and FD were t...

Rapamycin rescues mitochondrial dysfunction in cells carrying the m.8344A > G mutation in the mitochondrial tRNALys

Mariantonietta Capristo
Valentina Del Dotto
Concetta Valentina Tropeano
Claudio Fiorini
Leonardo Caporali
Chaira La Morgia
Maria Lucia Valentino
Monica Montopoli
Valerio Carelli
Alessandra Maresca

August 2022

PDF files containing western blot data from all the biological replicates analyzed

Rapamycin rescues mitochondrial dysfunction in cells carrying the m.8344A > G mutation in the mitochondrial tRNALys

Mariantonietta Capristo
Valentina Del Dotto
Concetta Valentina Tropeano
Claudio Fiorini
Leonardo Caporali
Chaira La Morgia
Maria Lucia Valentino
Monica Montopoli
Valerio Carelli
Alessandra Maresca

August 2022

PDF files containing western blot data from all the biological replicates analyzed

Rapamycin administration is not a valid therapeutic strategy for every case of mitochondrial disease.

Barriocanal-Casado, Eliana
Hidalgo-Gutiérrez, Agustín
Raimundo, Nuno
González-García, Pilar
Acuña-Castroviejo, Darío
Escames, Germaine
López, Luis C

March 2019

The vast majority of mitochondrial disorders have limited the clinical management to palliative care...

Long term rapamycin treatment improves mitochondrial DNA quality in aging mice

Bielas, Jason
Herbst, Allen
Widjaja, Kevin
Hui, Jessica
Aiken, Judd M
McKenzie, Debbie
Miller, Richard A
Brooks, Susan V
Wanagat, Jonathan

June 2018

Age-induced mitochondrial DNA deletion mutations may underlie cell loss and tissue aging. Rapamycin ...

Rapamycin ameliorates defects in mitochondrial fission and mitophagy in glioblastoma cells

Lenzi P.
Ferese R.
Biagioni F.
Fulceri F.
Busceti C. L.
Falleni A.
Gambardella S.
Frati A.
Fornai F.

January 2021

Glioblastoma (GBM) cells feature mitochondrial alterations, which are documented and quantified in t...

Rapamycin ameliorates defects in mitochondrial fission and mitophagy in glioblastoma cells

Lenzi P.
Ferese R.
Biagioni F.
Fulceri F.
Busceti C. L.
Falleni A.
Gambardella S.
Frati A.
Fornai F.

January 2021

Glioblastoma (GBM) cells feature mitochondrial alterations, which are documented and quantified in t...

Rapamycin Ameliorates Defects in Mitochondrial Fission and Mitophagy in Glioblastoma Cells

Lenzi, Paola
Ferese, Rosangela
Biagioni, Francesca
Fulceri, Federica
Busceti, Carla L
Falleni, Alessandra
Gambardella, Stefano
Frati, Alessandro
Fornai, Francesco

January 2021

Glioblastoma (GBM) cells feature mitochondrial alterations, which are documented and quantified in t...

Rapamycin Ameliorates Defects in Mitochondrial Fission and Mitophagy in Glioblastoma Cells

Lenzi, Paola
Ferese, Rosangela
Biagioni, Francesca
Fulceri, Federica
Busceti, Carla L
Falleni, Alessandra
Gambardella, Stefano
Frati, Alessandro
Fornai, Francesco

January 2021

Glioblastoma (GBM) cells feature mitochondrial alterations, which are documented and quantified in t...

Rapamycin ameliorates defects in mitochondrial fission and mitophagy in glioblastoma cells

Lenzi P.
Ferese R.
Biagioni F.
Fulceri F.
Busceti C. L.
Falleni A.
Gambardella S.
Frati A.
Fornai F.

January 2021

Glioblastoma (GBM) cells feature mitochondrial alterations, which are documented and quantified in t...

Rapamycin ameliorates defects in mitochondrial fission and mitophagy in glioblastoma cells

Lenzi P.
Ferese R.
Biagioni F.
Fulceri F.
Busceti C. L.
Falleni A.
Gambardella S.
Frati A.
Fornai F.

January 2021

Glioblastoma (GBM) cells feature mitochondrial alterations, which are documented and quantified in t...

Rapamycin Ameliorates Defects in Mitochondrial Fission and Mitophagy in Glioblastoma Cells

Lenzi, Paola
Ferese, Rosangela
Biagioni, Francesca
Fulceri, Federica
Busceti, Carla L
Falleni, Alessandra
Gambardella, Stefano
Frati, Alessandro
Fornai, Francesco

January 2021

Glioblastoma (GBM) cells feature mitochondrial alterations, which are documented and quantified in t...

Rapamycin Ameliorates Defects in Mitochondrial Fission and Mitophagy in Glioblastoma Cells

Lenzi, Paola
Ferese, Rosangela
Biagioni, Francesca
Fulceri, Federica
Busceti, Carla L
Falleni, Alessandra
Gambardella, Stefano
Frati, Alessandro
Fornai, Francesco

January 2021

Glioblastoma (GBM) cells feature mitochondrial alterations, which are documented and quantified in t...

Rapamycin inhibited mitochondrial mTOR and blocked radiation-induced bioenergetics switching.

Chung-Ling Lu (711442)
Lili Qin (365085)
Hsin-Chen Liu (546824)
Demet Candas (711443)
Ming Fan (102594)
Jian Jian Li (243325)

March 2015

<p>(A) Western blot of mTOR with mitochondria isolated from MCF-7 cells treated with 20 ng/mL rapamy...

Investigations into pathophysiologic mechanisms and treatment of primary mitochondrial diseases

Siegmund, Stephanie

January 2018

The present work addresses outstanding questions within the field of primary mitochondrial disease b...

Mitochondrial function is affected in GD and FD.

Margarita M. Ivanova (160805)
Erk Changsila (6199691)
Chidima Iaonou (6199694)
Ozlem Goker-Alpan (18201)

January 2019

(A) Effect of rapamycin (RAP) treatment on ATP levels. PBMCs from healthy subjects, GD and FD were t...

Rapamycin rescues mitochondrial dysfunction in cells carrying the m.8344A > G mutation in the mitochondrial tRNALys

Mariantonietta Capristo
Valentina Del Dotto
Concetta Valentina Tropeano
Claudio Fiorini
Leonardo Caporali
Chaira La Morgia
Maria Lucia Valentino
Monica Montopoli
Valerio Carelli
Alessandra Maresca

August 2022

PDF files containing western blot data from all the biological replicates analyzed

Rapamycin rescues mitochondrial dysfunction in cells carrying the m.8344A > G mutation in the mitochondrial tRNALys

Mariantonietta Capristo
Valentina Del Dotto
Concetta Valentina Tropeano
Claudio Fiorini
Leonardo Caporali
Chaira La Morgia
Maria Lucia Valentino
Monica Montopoli
Valerio Carelli
Alessandra Maresca

August 2022

PDF files containing western blot data from all the biological replicates analyzed

Rapamycin administration is not a valid therapeutic strategy for every case of mitochondrial disease.

Barriocanal-Casado, Eliana
Hidalgo-Gutiérrez, Agustín
Raimundo, Nuno
González-García, Pilar
Acuña-Castroviejo, Darío
Escames, Germaine
López, Luis C

March 2019

The vast majority of mitochondrial disorders have limited the clinical management to palliative care...

Long term rapamycin treatment improves mitochondrial DNA quality in aging mice

Bielas, Jason
Herbst, Allen
Widjaja, Kevin
Hui, Jessica
Aiken, Judd M
McKenzie, Debbie
Miller, Richard A
Brooks, Susan V
Wanagat, Jonathan

June 2018

Age-induced mitochondrial DNA deletion mutations may underlie cell loss and tissue aging. Rapamycin ...

Rapamycin ameliorates defects in mitochondrial fission and mitophagy in glioblastoma cells

Lenzi P.
Ferese R.
Biagioni F.
Fulceri F.
Busceti C. L.
Falleni A.
Gambardella S.
Frati A.
Fornai F.

January 2021

Glioblastoma (GBM) cells feature mitochondrial alterations, which are documented and quantified in t...

Rapamycin ameliorates defects in mitochondrial fission and mitophagy in glioblastoma cells

Lenzi P.
Ferese R.
Biagioni F.
Fulceri F.
Busceti C. L.
Falleni A.
Gambardella S.
Frati A.
Fornai F.

January 2021

Glioblastoma (GBM) cells feature mitochondrial alterations, which are documented and quantified in t...

Rapamycin Ameliorates Defects in Mitochondrial Fission and Mitophagy in Glioblastoma Cells

Lenzi, Paola
Ferese, Rosangela
Biagioni, Francesca
Fulceri, Federica
Busceti, Carla L
Falleni, Alessandra
Gambardella, Stefano
Frati, Alessandro
Fornai, Francesco

January 2021

Glioblastoma (GBM) cells feature mitochondrial alterations, which are documented and quantified in t...

Rapamycin Ameliorates Defects in Mitochondrial Fission and Mitophagy in Glioblastoma Cells

Lenzi, Paola
Ferese, Rosangela
Biagioni, Francesca
Fulceri, Federica
Busceti, Carla L
Falleni, Alessandra
Gambardella, Stefano
Frati, Alessandro
Fornai, Francesco

January 2021

Glioblastoma (GBM) cells feature mitochondrial alterations, which are documented and quantified in t...

Rapamycin ameliorates defects in mitochondrial fission and mitophagy in glioblastoma cells

Lenzi P.
Ferese R.
Biagioni F.
Fulceri F.
Busceti C. L.
Falleni A.
Gambardella S.
Frati A.
Fornai F.

January 2021

Glioblastoma (GBM) cells feature mitochondrial alterations, which are documented and quantified in t...

Rapamycin ameliorates defects in mitochondrial fission and mitophagy in glioblastoma cells

Lenzi P.
Ferese R.
Biagioni F.
Fulceri F.
Busceti C. L.
Falleni A.
Gambardella S.
Frati A.
Fornai F.

January 2021

Glioblastoma (GBM) cells feature mitochondrial alterations, which are documented and quantified in t...

Rapamycin Ameliorates Defects in Mitochondrial Fission and Mitophagy in Glioblastoma Cells

Lenzi, Paola
Ferese, Rosangela
Biagioni, Francesca
Fulceri, Federica
Busceti, Carla L
Falleni, Alessandra
Gambardella, Stefano
Frati, Alessandro
Fornai, Francesco

January 2021

Glioblastoma (GBM) cells feature mitochondrial alterations, which are documented and quantified in t...

Rapamycin Ameliorates Defects in Mitochondrial Fission and Mitophagy in Glioblastoma Cells

Lenzi, Paola
Ferese, Rosangela
Biagioni, Francesca
Fulceri, Federica
Busceti, Carla L
Falleni, Alessandra
Gambardella, Stefano
Frati, Alessandro
Fornai, Francesco

January 2021

Glioblastoma (GBM) cells feature mitochondrial alterations, which are documented and quantified in t...

Rapamycin inhibited mitochondrial mTOR and blocked radiation-induced bioenergetics switching.

Chung-Ling Lu (711442)
Lili Qin (365085)
Hsin-Chen Liu (546824)
Demet Candas (711443)
Ming Fan (102594)
Jian Jian Li (243325)

March 2015

<p>(A) Western blot of mTOR with mitochondria isolated from MCF-7 cells treated with 20 ng/mL rapamy...

Investigations into pathophysiologic mechanisms and treatment of primary mitochondrial diseases

Siegmund, Stephanie

January 2018

The present work addresses outstanding questions within the field of primary mitochondrial disease b...

Mitochondrial function is affected in GD and FD.

Margarita M. Ivanova (160805)
Erk Changsila (6199691)
Chidima Iaonou (6199694)
Ozlem Goker-Alpan (18201)

January 2019

(A) Effect of rapamycin (RAP) treatment on ATP levels. PBMCs from healthy subjects, GD and FD were t...

Rapamycin rescues mitochondrial dysfunction in cells carrying the m.8344A > G mutation in the mitochondrial tRNALys

Abstract

Extracted data

Rapamycin rescues mitochondrial dysfunction in cells carrying the m.8344A > G mutation in the mitochondrial tRNALys

Abstract

Extracted data

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