Development and Optimization of Cubosomal Econazole Nitrate

Cubosomes are nanoparticle, more accurately nano structure particles of a liquid crystalline phase with cubic crystallographic symmetry formed by the self-assembly of amphiphilic or surfactants like molecule. This study is to investigate the potential of cubosomes as lipid nanocarrier to improve the controlled release of Econazole Nitrate used for treatment of dermatophytes. Econazole Nitrate cubosomes were prepared by Top-down approach employing GMO as lipid phase vehicle, Poloxamer 407 as stabilizer and distilled water as aqueous phase. The resultant cubosomes dispersion were characterized by encapsulation efficiency, in-vitro drug release, particle size, zeta potential and FTIR. Best formulation (F4) showed a maximum drug release of 93.96 % in 8 hours, particle size of 230.1 nm and zeta potential of -19.1 mV. The best formulation was chosen on the basis of Optimization by Design of Expert software which will be incorporated into the carbopol 934 gel for the proper and feasible application of the formulation on skin.http://impactfactor.org/PDF/IJCPR/14/IJCPR,Vol14,Issue4,Article4.pd