INVESTIGATION FOR ANALGESIC AND ANTI- INFLAMMATORY ACTIVITIES USING ETHANOLIC ROOT EXTRACT OF ACONITUM ATROX AND LEAF EXTRACT OF CONIUM MACULATUM ON ANIMAL MODELS

The assertion of the pharmacology of natural product is to explore benefits of natural resources for the mankind. Drugs extracted from natural resources are considered as primary source for drug discovery. Thus, the current study was designed to evaluate the safety profile and explore the analgesic and anti-inflammatory activity of ethanol extract of root of Aconitum atrox and leaf of Conium maculatum. They have been used for several therapeutic purposes. Eddy’s hot plate methods was used to assess analgesic activity while anti-inflammatory activity was evaluated by carrageenan induced paw edema method. The root extracts of A. atrox and leaf extract of C. maculatum were found to be safe and showed significant analgesic and anti-inflammatory activity in comparison with the control group. The therapeutic effects of these extracts were almost comparable to aspirin and indomethacin. Therefore, their root and leaf can be used as effective analgesic and anti-inflammatory agents. Keywords: Analgesic activity, Anti-inflammatory activity, Extract, Herbal medicine, Aconitum atrox and Conium maculatum, Eddy’s hot plate, Carrageenan induced paw edema, cox-assay methods