Effects of early amino acid administration on leucine and glucose kinetics in premature infants
- Van Den Akker, Chris H.P.
- Te Braake, Frans W.J.
- Wattimena, Darcos J.L.
- Voortman, Gardi
- Schierbeek, Henk
- Vermes, Andras
- Van Goudoever, Johannes B.
DOIAbstract
We previously showed that, in prematurely born infants, an anabolic state without metabolic acidosis can be achieved upon intravenous amino acid (AA) administration in the immediate postnatal phase, despite a low energy intake. We hypothesized that the anabolic state resulted from an increased protein synthesis and not a decreased proteolysis. Furthermore, we hypothesized that the energy needed for the higher protein synthesis rate would be derived from an increased glucose oxidation. To test our hypotheses, 32 ventilated premature infants (<1500 g) received intravenously either solely glucose or glucose and 2.4 g AA/kg/d immediately postnatally. On postnatal d 2, each group received primed continuous infusions of either [1- 13C]leucine or ...
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