An approach to generate new neurons after central nervous system injury or disease is direct reprogramming of the individual's own somatic cells into differentiated neurons. This can be achieved either by transduction of viral vectors that express neurogenic transcription factors and/or through induction with small molecules, avoiding introducing foreign genetic material in target cells. In this work, we propose olfactory ensheathing glia (OEG) as a candidate for direct reprogramming to neurons with small molecules due to its well-characterized neuro-regenerative capacity. After screening different combinations of small molecules in different culture conditions, only partial reprogramming was achieved: induced cells expressed neuronal marke...
Olfactory ensheathing glia (OEG) accompany olfactory growing axons in their entry to the adult mamma...
The intrinsic regenerative capacity of the adult mammalian central nervous system (CNS) is limited b...
Adenoviral (AdV) vectors encoding neurotrophin-3 (AdV-NT-3) or the bacterial marker enzyme beta-gala...
An approach to generate new neurons after central nervous system injury or disease is direct reprogr...
An approach to generate new neurons after central nervous system injury or disease is direct reprogr...
An approach to generate new neurons after central nervous system injury or disease is direct reprogr...
An approach to generate new neurons after central nervous system injury or disease is direct reprogr...
An approach to generate new neurons after central nervous system injury or disease is direct reprogr...
SummaryWe have recently demonstrated that reactive glial cells can be directly reprogrammed into fun...
Chemical reprogramming of astrocytes into neurons represents a promising approach to regenerate new ...
Olfactory ensheathing glia (OEG) cells are known to foster axonal regeneration of central nervous sy...
Olfactory bulb ensheathing glia (OEG) have attracted special attention during the last few years bec...
International audienceSubventricular zone (SVZ) neurogenesis continuously provides new GABA-and dopa...
SummaryRecently, direct reprogramming between divergent lineages has been achieved by the introducti...
The adult mammalian central nervous system harbors a population of neural stem cells with the abilit...
Olfactory ensheathing glia (OEG) accompany olfactory growing axons in their entry to the adult mamma...
The intrinsic regenerative capacity of the adult mammalian central nervous system (CNS) is limited b...
Adenoviral (AdV) vectors encoding neurotrophin-3 (AdV-NT-3) or the bacterial marker enzyme beta-gala...
An approach to generate new neurons after central nervous system injury or disease is direct reprogr...
An approach to generate new neurons after central nervous system injury or disease is direct reprogr...
An approach to generate new neurons after central nervous system injury or disease is direct reprogr...
An approach to generate new neurons after central nervous system injury or disease is direct reprogr...
An approach to generate new neurons after central nervous system injury or disease is direct reprogr...
SummaryWe have recently demonstrated that reactive glial cells can be directly reprogrammed into fun...
Chemical reprogramming of astrocytes into neurons represents a promising approach to regenerate new ...
Olfactory ensheathing glia (OEG) cells are known to foster axonal regeneration of central nervous sy...
Olfactory bulb ensheathing glia (OEG) have attracted special attention during the last few years bec...
International audienceSubventricular zone (SVZ) neurogenesis continuously provides new GABA-and dopa...
SummaryRecently, direct reprogramming between divergent lineages has been achieved by the introducti...
The adult mammalian central nervous system harbors a population of neural stem cells with the abilit...
Olfactory ensheathing glia (OEG) accompany olfactory growing axons in their entry to the adult mamma...
The intrinsic regenerative capacity of the adult mammalian central nervous system (CNS) is limited b...
Adenoviral (AdV) vectors encoding neurotrophin-3 (AdV-NT-3) or the bacterial marker enzyme beta-gala...