Coronary artery disease (CAD) is the most common cardiovascular disease (CVD), and previous studies have shown a significant association between N-glycosylation, a highly regulated posttranslational modification, and the development of atherosclerotic plaques. Our aim was to determine whether the N-glycome of immunoglobulin G (IgG) is associated with CAD, as N-glycans are known to alter the effector functions of IgG, which may enhance the inflammatory response in CAD. Therefore, in this study, we isolated IgG from subjects with coronary atherosclerosis (CAD+) and from subjects with clean coronaries (CAD−). The purified IgGs were denatured and enzymatically deglycosylated, and the released and fluorescently labelled N-glycans were analysed b...
BACKGROUND: Statins are among the most widely prescribed medications worldwide and usually many indi...
Objective Type 2 diabetes (T2DM) is a complicated and comprehensive disease that has many metabolic...
N-linked glycans on immunoglobulin G (IgG) have been associated with pathogenesis of diseases and th...
Coronary artery disease (CAD) is the most common cardiovascular disease (CVD), resulting from chron...
Rationale:One measure of protein glycosylation (GlycA) has been reported to predict higher cardiovas...
Abstract Background Glycosylation significantly affects protein structure and function and thus part...
Introduction Immune-inflammatory response plays a key role in the pathogenesis of atherosclerosis. I...
Abstract Background Alternative N-glycosylation has significant structural and functional consequenc...
Objectives: Hypertension and type 2 diabetes mellitus comorbidity (HDC) is common, which confers a h...
OBJECTIVE N-glycosylation is a functional posttranslational modification of immunoglobulins (Igs). W...
Background: Evidence suggests that immunoglobulin G (IgG) N-glycosylation is associated with ischemi...
Cardiovascular disease is a common complex trait that calls for next-generation biomarkers for preci...
All immunoglobulin G molecules carry N-glycans, which modulate their biological activity. Changes in...
All immunoglobulin G molecules carry N-glycans, which modulate their biological activity. Changes in...
Background-—Glycosylated proteins partake in multiple cellular processes including inflammation. We ...
BACKGROUND: Statins are among the most widely prescribed medications worldwide and usually many indi...
Objective Type 2 diabetes (T2DM) is a complicated and comprehensive disease that has many metabolic...
N-linked glycans on immunoglobulin G (IgG) have been associated with pathogenesis of diseases and th...
Coronary artery disease (CAD) is the most common cardiovascular disease (CVD), resulting from chron...
Rationale:One measure of protein glycosylation (GlycA) has been reported to predict higher cardiovas...
Abstract Background Glycosylation significantly affects protein structure and function and thus part...
Introduction Immune-inflammatory response plays a key role in the pathogenesis of atherosclerosis. I...
Abstract Background Alternative N-glycosylation has significant structural and functional consequenc...
Objectives: Hypertension and type 2 diabetes mellitus comorbidity (HDC) is common, which confers a h...
OBJECTIVE N-glycosylation is a functional posttranslational modification of immunoglobulins (Igs). W...
Background: Evidence suggests that immunoglobulin G (IgG) N-glycosylation is associated with ischemi...
Cardiovascular disease is a common complex trait that calls for next-generation biomarkers for preci...
All immunoglobulin G molecules carry N-glycans, which modulate their biological activity. Changes in...
All immunoglobulin G molecules carry N-glycans, which modulate their biological activity. Changes in...
Background-—Glycosylated proteins partake in multiple cellular processes including inflammation. We ...
BACKGROUND: Statins are among the most widely prescribed medications worldwide and usually many indi...
Objective Type 2 diabetes (T2DM) is a complicated and comprehensive disease that has many metabolic...
N-linked glycans on immunoglobulin G (IgG) have been associated with pathogenesis of diseases and th...