IRX genes are members of the TALE homeobox gene class and encode six related transcription factors (IRX1–IRX6) controlling development and cell differentiation of several tissues in humans. Classification of TALE homeobox gene expression patterns for the hematopoietic compartment, termed TALE-code, has revealed exclusive IRX1 activity in pro-B-cells and megakaryocyte erythroid progenitors (MEPs), highlighting its specific contribution to developmental processes at these early stages of hematopoietic lineage differentiation. Moreover, aberrant expression of IRX homeobox genes IRX1, IRX2, IRX3 and IRX5 has been detected in hematopoietic malignancies, including B-cell precursor acute lymphoblastic leukemia (BCP-ALL), T-cell ALL, and some subty...
The caudal-related homeobox transcription factor CDX2 is expressed in leukemic cells but not during ...
The hallmark of hematopoietic stem cells (HSC) is their ability of self-renewal and differentiation ...
Hematopoietic stem cells (HSCs) are functionally defined as cells that upon transplantation into irr...
Homeobox genes encode transcription factors regulating basic developmental processes. They are arran...
The Iroquois homeodomain transcription factor gene IRX3 is expressed in the developing nervous syste...
Homeobox genes encode transcription factors which regulate basic processes in development and cell d...
The Homeobox (Hox) gene network in conjunction with their Tale cofactors act as master regulators of...
Hematopoiesis is a complex process by which billions of mature cells are produced from a small pool ...
The homeobox (HOX) genes are a highly conserved family of homeodomain-containing transcription facto...
__Background:__ Although distinct patterns of homeobox (HOX) gene expression have been described in ...
The hematopoietically expressed homeobox (Hhex) transcription factor is overexpressed in human myelo...
T-cell acute lymphoblastic leukemia (T-ALL) cells represent developmentally arrested T-cell progenit...
SummaryHomeobox domain-containing transcription factors are important regulators of hematopoiesis. H...
Caudal (Cdx) genes encode homeobox transcription factors that regulate Hox gene expression. There ar...
Iroquois transcription factor gene IRX3 is highly expressed in 20-30% of acute myeloid leukemia (AML...
The caudal-related homeobox transcription factor CDX2 is expressed in leukemic cells but not during ...
The hallmark of hematopoietic stem cells (HSC) is their ability of self-renewal and differentiation ...
Hematopoietic stem cells (HSCs) are functionally defined as cells that upon transplantation into irr...
Homeobox genes encode transcription factors regulating basic developmental processes. They are arran...
The Iroquois homeodomain transcription factor gene IRX3 is expressed in the developing nervous syste...
Homeobox genes encode transcription factors which regulate basic processes in development and cell d...
The Homeobox (Hox) gene network in conjunction with their Tale cofactors act as master regulators of...
Hematopoiesis is a complex process by which billions of mature cells are produced from a small pool ...
The homeobox (HOX) genes are a highly conserved family of homeodomain-containing transcription facto...
__Background:__ Although distinct patterns of homeobox (HOX) gene expression have been described in ...
The hematopoietically expressed homeobox (Hhex) transcription factor is overexpressed in human myelo...
T-cell acute lymphoblastic leukemia (T-ALL) cells represent developmentally arrested T-cell progenit...
SummaryHomeobox domain-containing transcription factors are important regulators of hematopoiesis. H...
Caudal (Cdx) genes encode homeobox transcription factors that regulate Hox gene expression. There ar...
Iroquois transcription factor gene IRX3 is highly expressed in 20-30% of acute myeloid leukemia (AML...
The caudal-related homeobox transcription factor CDX2 is expressed in leukemic cells but not during ...
The hallmark of hematopoietic stem cells (HSC) is their ability of self-renewal and differentiation ...
Hematopoietic stem cells (HSCs) are functionally defined as cells that upon transplantation into irr...