Pancreatic cancer is a devastating disease with a dismal prognosis and poor treatment outcomes. Searching for new agents for pancreatic cancer treatment is of great significance. We previously identified a novel activity of compound C150 to inhibit pancreatic cancer epithelial-to-mesenchymal transition (EMT). Here, we further revealed its mechanism of action. C150 induced ER stress in pancreatic cancer cells and subsequently increased proteasome activity by enhancing proteasome assembly, which subsequently enhanced the degradation of critical EMT transcription factors (EMT-TFs). In addition, as cellular responses to ER stress, autophagy was elevated, and general protein synthesis was inhibited in pancreatic cancer cells. Besides EMT inhibit...
Pancreatic cancer is one of the most lethal diseases, which has 5-year survival rate of under 8% and...
Pachymic acid (PA) is a purified triterpene extracted from medicinal fungus Poria cocos. In this pap...
Pancreatic cancer is the fourth leading cause of cancer-related death in the United States, and it i...
Pancreatic cancer is a devastating disease with a current overall 5-year survival rate of only 10%, ...
Pancreatic cancer cell epithelial-to-mesenchymal transition (EMT) is an important contributor to cel...
Pancreatic cancer is the 4th leading cause of cancer-related death in the U.S. in 2019. The five-yea...
Bortezomib (VELCADE™, formerly known as PS-341) is a selective and potent inhibitor of the proteasom...
Bortezomib (VELCADE™, formerly known as PS-341) is a selective and potent inhibitor of the proteasom...
© 2021 by the authors.Pancreatic cancer is one of the most lethal malignancies with a poor and gloom...
Pancreatic ductal adenocarcinoma (PDAC) represents the fourth most common cause of cancer-associated...
32 p.-11 fig.Pancreatic ductal adenocarcinoma (PDAC), the most common malignancy of the pancreas, sh...
Pancreatic ductal adenocarcinoma (PDAC), the most common malignancy of the pancreas, shows a dismal ...
Endoplasmic reticulum stress from unfolded proteins is associated with the proliferation of pancreat...
Background Pancreatic cancer has an enrichment of stem-like cancer cells (CSCs) that contribute t...
A critical regulator of the unfolded protein response (UPR), the IRE1α kinase/endoribonuclease promo...
Pancreatic cancer is one of the most lethal diseases, which has 5-year survival rate of under 8% and...
Pachymic acid (PA) is a purified triterpene extracted from medicinal fungus Poria cocos. In this pap...
Pancreatic cancer is the fourth leading cause of cancer-related death in the United States, and it i...
Pancreatic cancer is a devastating disease with a current overall 5-year survival rate of only 10%, ...
Pancreatic cancer cell epithelial-to-mesenchymal transition (EMT) is an important contributor to cel...
Pancreatic cancer is the 4th leading cause of cancer-related death in the U.S. in 2019. The five-yea...
Bortezomib (VELCADE™, formerly known as PS-341) is a selective and potent inhibitor of the proteasom...
Bortezomib (VELCADE™, formerly known as PS-341) is a selective and potent inhibitor of the proteasom...
© 2021 by the authors.Pancreatic cancer is one of the most lethal malignancies with a poor and gloom...
Pancreatic ductal adenocarcinoma (PDAC) represents the fourth most common cause of cancer-associated...
32 p.-11 fig.Pancreatic ductal adenocarcinoma (PDAC), the most common malignancy of the pancreas, sh...
Pancreatic ductal adenocarcinoma (PDAC), the most common malignancy of the pancreas, shows a dismal ...
Endoplasmic reticulum stress from unfolded proteins is associated with the proliferation of pancreat...
Background Pancreatic cancer has an enrichment of stem-like cancer cells (CSCs) that contribute t...
A critical regulator of the unfolded protein response (UPR), the IRE1α kinase/endoribonuclease promo...
Pancreatic cancer is one of the most lethal diseases, which has 5-year survival rate of under 8% and...
Pachymic acid (PA) is a purified triterpene extracted from medicinal fungus Poria cocos. In this pap...
Pancreatic cancer is the fourth leading cause of cancer-related death in the United States, and it i...