SCOPE: Low-calorie sweetener (LCS) consumption is associated with metabolic disease in observational studies. However, physiologic mechanisms underlying LCS-induced metabolic impairments in humans are unclear. This study is aimed at identifying molecular pathways in adipose impacted by LCSs. METHODS AND RESULTS: Seven females with overweight or obesity, who did not report LCS use, consumed 12 ounces of diet soda containing sucralose and acesulfame-potassium (Ace-K) three times daily for 8 weeks. A subcutaneous adipose biopsy from the left abdomen and a fasting blood sample were collected at baseline and post-intervention. Global gene expression were assessed using RNA-sequencing followed by functional pathway analysis. No differences in ci...
The usage of aspartame, as one of the most widely used sweetener, has been approved in many types of...
BackgroundHigh carbohydrate, i.e., sugars, intake potentially drives the liver into a lipogenic stat...
Objective: Whether sucralose, the most commonly used non-nutritive sweetener (NNS), affects glucose ...
Scope: Low-calorie sweetener (LCS) consumption is associated with metabolic disease in observational...
With consistent high rates of consumption of low-calorie sweeteners (LCS) among the US adult populat...
Artificial sweeteners are extensively used as alternatives for caloric sugars, particularly among in...
BACKGROUND: Consumption of low–calorie sweeteners (LCS)—including acesulfame-potassium, aspartame, s...
Consumption of low calorie sweeteners (LCS) is associated with development of metabolic diseases in ...
Background: Products containing low-calorie sweeteners (LCS), including acesulfame-potassium, aspart...
Background. Sugar-sweetened beverage (SSB) consumption is highly associated with obesity, but the me...
Epidemiologic studies report associations between artificial sweetener (ASW) consumption and metabol...
Thesis (Ph.D.)--University of Washington, 2016-04The epidemics of obesity and related metabolic dise...
Epidemiologic studies report associations between artificial sweetener (ASW) consumption and metabol...
Artificial sweeteners have been widely used in the modern diet, and their observed effects on human ...
International audienceThe excess consumption of added sugar is consistently found to be associated w...
The usage of aspartame, as one of the most widely used sweetener, has been approved in many types of...
BackgroundHigh carbohydrate, i.e., sugars, intake potentially drives the liver into a lipogenic stat...
Objective: Whether sucralose, the most commonly used non-nutritive sweetener (NNS), affects glucose ...
Scope: Low-calorie sweetener (LCS) consumption is associated with metabolic disease in observational...
With consistent high rates of consumption of low-calorie sweeteners (LCS) among the US adult populat...
Artificial sweeteners are extensively used as alternatives for caloric sugars, particularly among in...
BACKGROUND: Consumption of low–calorie sweeteners (LCS)—including acesulfame-potassium, aspartame, s...
Consumption of low calorie sweeteners (LCS) is associated with development of metabolic diseases in ...
Background: Products containing low-calorie sweeteners (LCS), including acesulfame-potassium, aspart...
Background. Sugar-sweetened beverage (SSB) consumption is highly associated with obesity, but the me...
Epidemiologic studies report associations between artificial sweetener (ASW) consumption and metabol...
Thesis (Ph.D.)--University of Washington, 2016-04The epidemics of obesity and related metabolic dise...
Epidemiologic studies report associations between artificial sweetener (ASW) consumption and metabol...
Artificial sweeteners have been widely used in the modern diet, and their observed effects on human ...
International audienceThe excess consumption of added sugar is consistently found to be associated w...
The usage of aspartame, as one of the most widely used sweetener, has been approved in many types of...
BackgroundHigh carbohydrate, i.e., sugars, intake potentially drives the liver into a lipogenic stat...
Objective: Whether sucralose, the most commonly used non-nutritive sweetener (NNS), affects glucose ...