Indiana University-Purdue University Indianapolis (IUPUI)Kidney disease and nephrolithiasis both present a major burden on the health care system in the US and worldwide. The cellular and molecular events governing the pathogenesis of these diseases are not fully understood. We propose that defining the cellular heterogeneity and niches in human and mouse kidney tissue specimens from controls and various models of renal disease could provide unique insights into the molecular pathogenesis. For that purpose, a multiplexed fluorescence imaging approach using co-detection by Indexing (CODEX) was used, using a panel of 33 and 38 markers for mouse and human kidney tissues, respectively. A customized computational analytical pipeline was develope...
The purpose of the thesis was to study the pathogenesis of Autosomal Dominant Polycystic Kidney Dise...
We developed an experimental set up that enables longitudinal studies of immune cell behavior in sit...
Kidney diseases manifest in progressive loss of renal function, which ultimately leads to complete k...
Recent developments in optical tissue clearing have been difficult to apply for the morphometric ana...
Background Little is known about the roles of myeloid cell subsets in kidney injury and in the limit...
Acute kidney injury (AKI) is a risk factor for chronic kidney disease (CKD), but the cellular mechan...
Background: The kidney is a highly complex organ that performs diverse functions that are essential ...
Analysis of the immune system in the kidney relies predominantly on flow cytometry. Although powerfu...
Intravital two-photon microscopy is a powerful imaging tool for investigating various biological pro...
Kidney biopsy remains the gold standard for uncovering the pathogenesis of acute and chronic kidney ...
The kidney is a structurally and functionally complex organ responsible for the control of water, io...
Lupus Nephritis is a chronic inflammatory kidney disease that arises in the context of systemic lupu...
Kidney Precision Medicine Project (KPMP) is building a spatially specified human kidney tissue atlas...
The development of intravital imaging with multiphoton microscopy has had a major impact on kidney r...
Here, we describe the preservation and preparation of human kidney tissue for interrogation by histo...
The purpose of the thesis was to study the pathogenesis of Autosomal Dominant Polycystic Kidney Dise...
We developed an experimental set up that enables longitudinal studies of immune cell behavior in sit...
Kidney diseases manifest in progressive loss of renal function, which ultimately leads to complete k...
Recent developments in optical tissue clearing have been difficult to apply for the morphometric ana...
Background Little is known about the roles of myeloid cell subsets in kidney injury and in the limit...
Acute kidney injury (AKI) is a risk factor for chronic kidney disease (CKD), but the cellular mechan...
Background: The kidney is a highly complex organ that performs diverse functions that are essential ...
Analysis of the immune system in the kidney relies predominantly on flow cytometry. Although powerfu...
Intravital two-photon microscopy is a powerful imaging tool for investigating various biological pro...
Kidney biopsy remains the gold standard for uncovering the pathogenesis of acute and chronic kidney ...
The kidney is a structurally and functionally complex organ responsible for the control of water, io...
Lupus Nephritis is a chronic inflammatory kidney disease that arises in the context of systemic lupu...
Kidney Precision Medicine Project (KPMP) is building a spatially specified human kidney tissue atlas...
The development of intravital imaging with multiphoton microscopy has had a major impact on kidney r...
Here, we describe the preservation and preparation of human kidney tissue for interrogation by histo...
The purpose of the thesis was to study the pathogenesis of Autosomal Dominant Polycystic Kidney Dise...
We developed an experimental set up that enables longitudinal studies of immune cell behavior in sit...
Kidney diseases manifest in progressive loss of renal function, which ultimately leads to complete k...