The recent development of the research field of Computing and Philosophy has triggered investigations into the theoretical foundations of computing and information. This thesis consists of two parts which are the result of studies in two areas of Philosophy of Computing (PC) and Philosophy of Information (PI) regarding the production of meaning (semantics) and the value system with applications (ethics). The first part develops a unified dual-aspect theory of information and computation, in which information is characterized as structure, and computation is the information dynamics. This enables naturalization of epistemology, based on interactive information representation and communication. In the study of systems modeling, meaning, truth...