Risk Factors of Multidrug-resistant Tuberculosis (MDR-TB) at Serui Regional General Hospital, Kepulauan Yapen Regency, Papua Province

Background: Tuberculosis, often known as TB, is a disease caused by an infection with the bacteria Mycobacterium tuberculosis. Patients who are not obedient and do not take their medicine on a regular basis will develop drug resistance, including Multidrug-resistant Tuberculosis (MDR-TB: resistant to INH and RIF), as well as concomitant illnesses. These variables can be modified by TB patients' characteristics like as age, gender, ethnicity, education, profession, side effects, medication supervisors, and co-morbidities. Objectives: The goal of this study is to identify the factors influencing MDR TB in Serui Regional General Hospital, Kepulauan Yapen Regency in 2022. Methods: This type of research is an observational study with a case control approach. The population consisted of 52 TB patients consisting of 26 cases and 26 controls by purposive sampling. Data were obtained from medical record data, and analyzed using chi square, odds ratio and binary logistic regression. Result: The results showed that the factors that had a significant effect on MDR-TB in Serui Regional General Hospital, Kepulauan Yapen Regency in 2022 were age (p-value = 0.002; OR = 8.8(2.336-33.152), gender (p-value = 0.049, OR = 3.701(1.156-11.861), ethnicity (p-value= 0.001 ; OR = 9.450(2.621-34.073), education (p-value= 0.002; OR = 12(2.340-61.520), occupation (p-value= 0.046; OR = 3.889 (1.178-12.841), side effects (p-value= 0.021; OR = 4.9(1.413-16.988), co-morbidity (p-value= 0.003; OR = 18.33(2.147-156.583). Factors that are not influence on MDR TB in Serui Regional General Hospital, Kepulauan Yapen Regency in 2022 was the drug taking supervisor (p-value = 0.771; OR = 0.711 (0.226-2.241). The dominant factors influencing MDR TB in Serui Regional General Hospital, Kepulauan Yapen Regency in 2022 were age, gender, education, occupation and co-morbidity, while education was the most dominant risk factors