Background: Autism spectrum disorder (ASD) threatens one’s socialization ability, and a lack of social skills can cause dysfunctions and mental health problems for adolescents. This study aimed to investigate the effect of communication skills training and enrichment on social responsiveness and social communication skills of adolescents with autism spectrum disorder and their parents in Shiraz. Methods: The study method was quasi-experimental with a pre-test and post-test design and a control group. The statistical population comprised adolescents with ASD at clinics in Shiraz, Iran, in 2019. The sample was selected from adolescents who had been diagnosed with ASD by the Exceptional Education Organization of Fars Province, and the particip...