Aims: Variants of the junctional cadherin 5 associated (JCAD) locus associate with acute coronary syndromes. JCAD promotes experimental atherosclerosis through the large tumor suppressor kinase 2 (LATS2)/Hippo pathway. This study investigates the role of JCAD in arterial thrombosis. Methods and results: JCAD knockout (Jcad-/-) mice underwent photochemically induced endothelial injury to trigger arterial thrombosis. Primary human aortic endothelial cells (HAECs) treated with JCAD small interfering RNA (siJCAD), LATS2 small interfering RNA (siLATS2) or control siRNA (siSCR) were employed for in vitro assays. Plasma JCAD was measured in patients with chronic coronary syndrome or ST-elevation myocardial infarction (STEMI). Jcad-/- mice displ...
BackgroundRecanalization is an important physiologic phenomenon because it can efficiently reestabli...
Cardiovascular diseases (CVDs) including Acute Coronary Syndromes (ACS) and stroke, are the main cau...
Although cardiovascular disease (CVD) is the leading cause of morbimortality worldwide, promising ne...
Aims: Variants of the junctional cadherin 5 associated (JCAD) locus associate with acute coronary sy...
INTRODUCTION: Genome Wide Association studies have consistently identified an association between co...
Objective— A large number of genetic loci have been associated with risk of coronary artery disease ...
OBJECTIVE: A large number of genetic loci have been associated with risk of coronary artery disease ...
Aims: Arterial thrombosis as a result of plaque rupture or erosion is a key event in acute cardiovas...
BACKGROUND: Sirtuin 3 (Sirt3) is a mitochondrial, nicotinamide adenine dinucleotide (NAD+)-dependent...
Akt is a pivotal signaling molecule involved in the regulation of angiogenesis. In order to further ...
Rationale: Phosphoinositide 3-kinase (PI3K)γ is expressed in hematopoietic cells, endothelial cells ...
RATIONALE: Arterial inflammation manifested as atherosclerosis is the leading cause of mortality wor...
Endothelial cell (EC) sensing of disturbed blood flow triggers atherosclerosis, a disease of arterie...
Spontaneous coronary artery dissection (SCAD) and coronary artery disease (CAD) both represent cardi...
Aims: Medical treatment of arterial thrombosis is mainly directed against platelets and coagulation ...
BackgroundRecanalization is an important physiologic phenomenon because it can efficiently reestabli...
Cardiovascular diseases (CVDs) including Acute Coronary Syndromes (ACS) and stroke, are the main cau...
Although cardiovascular disease (CVD) is the leading cause of morbimortality worldwide, promising ne...
Aims: Variants of the junctional cadherin 5 associated (JCAD) locus associate with acute coronary sy...
INTRODUCTION: Genome Wide Association studies have consistently identified an association between co...
Objective— A large number of genetic loci have been associated with risk of coronary artery disease ...
OBJECTIVE: A large number of genetic loci have been associated with risk of coronary artery disease ...
Aims: Arterial thrombosis as a result of plaque rupture or erosion is a key event in acute cardiovas...
BACKGROUND: Sirtuin 3 (Sirt3) is a mitochondrial, nicotinamide adenine dinucleotide (NAD+)-dependent...
Akt is a pivotal signaling molecule involved in the regulation of angiogenesis. In order to further ...
Rationale: Phosphoinositide 3-kinase (PI3K)γ is expressed in hematopoietic cells, endothelial cells ...
RATIONALE: Arterial inflammation manifested as atherosclerosis is the leading cause of mortality wor...
Endothelial cell (EC) sensing of disturbed blood flow triggers atherosclerosis, a disease of arterie...
Spontaneous coronary artery dissection (SCAD) and coronary artery disease (CAD) both represent cardi...
Aims: Medical treatment of arterial thrombosis is mainly directed against platelets and coagulation ...
BackgroundRecanalization is an important physiologic phenomenon because it can efficiently reestabli...
Cardiovascular diseases (CVDs) including Acute Coronary Syndromes (ACS) and stroke, are the main cau...
Although cardiovascular disease (CVD) is the leading cause of morbimortality worldwide, promising ne...