Purpose: Acyclovir is most commonly used for treating ocular Herpes Keratitis, a leading cause of infectious blindness. However, emerging resistance to Acyclovir resulting from mutations in the thymidine kinase gene of Herpes Simplex Virus −1 (HSV-1), has prompted the need for new therapeutics directed against a different viral protein. One novel target is the HSV-1 Processivity Factor which is essential for tethering HSV-1 Polymerase to the viral genome to enable long-chain DNA synthesis. Methods: A series of peptides, based on the crystal structure of the C-terminus of HSV-1 Polymerase, were constructed with hydrocarbon staples to retain their alpha-helical conformation. The stapled peptides were tested for blocking both HSV-1 DNA synthes...
Herpes simplex keratitis (HSK), caused by herpes simplex virus type 1 (HSV‑1) infection, is the comm...
HSV-1-induced corneal scarring (CS), also broadly referred to as Herpes Stromal Keratitis (HSK), is ...
Herpes simplex virus (HSV) is a human pathogen that infects epithelial cells. The cutaneous lesions,...
© 2019, The Author(s). In order to evaluate the influence of CDK5 inhibitory peptide (CIP) on Human ...
Heparan sulfate (HS) and its highly modified form, 3-O-sulfated heparan sulfate (3-OS HS), contribut...
Herpes simplex virus (HSV) is a significant human pathogen causing mucocutaneous lesions primarily i...
In order to evaluate the influence of CDK5 inhibitory peptide (CIP) on Human alphaherpesvirus 1 (HSV...
Infections with the herpes simplex virus can lead to severe corneal scarring and opacity. The curren...
Herpes simplex virus type 1 (HSV-1) is a common virus of mankind and HSV-1 infections are a signific...
Human cytomegalovirus (HCMV) infection can lead to congenital hearing loss and mental retardation. U...
Herpes simplex virus (HSV-1) employs heparan sulfate (HS) as receptor for cell attachment and entry....
Introduction. Herpetic keratitis caused by the herpes simplex virus (HSV) is the most common form of...
HSV-1 can be associated with severe and recurrent eye infections characterized by a strong inflammat...
Purpose: To evaluate the broad-spectrum antiviral activity of peptide H9 (H9) in vitro in order to g...
AbstractThe interaction between the catalytic subunit Pol and the processivity subunit UL42 of herpe...
Herpes simplex keratitis (HSK), caused by herpes simplex virus type 1 (HSV‑1) infection, is the comm...
HSV-1-induced corneal scarring (CS), also broadly referred to as Herpes Stromal Keratitis (HSK), is ...
Herpes simplex virus (HSV) is a human pathogen that infects epithelial cells. The cutaneous lesions,...
© 2019, The Author(s). In order to evaluate the influence of CDK5 inhibitory peptide (CIP) on Human ...
Heparan sulfate (HS) and its highly modified form, 3-O-sulfated heparan sulfate (3-OS HS), contribut...
Herpes simplex virus (HSV) is a significant human pathogen causing mucocutaneous lesions primarily i...
In order to evaluate the influence of CDK5 inhibitory peptide (CIP) on Human alphaherpesvirus 1 (HSV...
Infections with the herpes simplex virus can lead to severe corneal scarring and opacity. The curren...
Herpes simplex virus type 1 (HSV-1) is a common virus of mankind and HSV-1 infections are a signific...
Human cytomegalovirus (HCMV) infection can lead to congenital hearing loss and mental retardation. U...
Herpes simplex virus (HSV-1) employs heparan sulfate (HS) as receptor for cell attachment and entry....
Introduction. Herpetic keratitis caused by the herpes simplex virus (HSV) is the most common form of...
HSV-1 can be associated with severe and recurrent eye infections characterized by a strong inflammat...
Purpose: To evaluate the broad-spectrum antiviral activity of peptide H9 (H9) in vitro in order to g...
AbstractThe interaction between the catalytic subunit Pol and the processivity subunit UL42 of herpe...
Herpes simplex keratitis (HSK), caused by herpes simplex virus type 1 (HSV‑1) infection, is the comm...
HSV-1-induced corneal scarring (CS), also broadly referred to as Herpes Stromal Keratitis (HSK), is ...
Herpes simplex virus (HSV) is a human pathogen that infects epithelial cells. The cutaneous lesions,...