Low-grade serous ovarian cancer (LGSOC) is a rare subtype of epithelial ovarian cancer with high fatality rates in advanced stages due to its chemo-resistant properties. LGSOC is characterized by activation of MAPK signaling and recent clinical trials indicate that the MEK inhibitor (MEKi) trametinib may be a good treatment option for a subset of patients. Understanding MEKi resistance mechanisms and subsequent identification of rational drug combinations to suppress resistance may greatly improve LGSOC treatment strategies. Both gain-of-function and loss-of-function CRISPR-Cas9 genome-wide libraries were used to screen LGSOC cell lines to identify genes that modulate the response to MEKi. Overexpression of MAML2 and loss of MAP3K1 were ide...
International audienceOvarian cancer is a silent disease with a poor prognosis that urgently require...
International audienceOvarian cancer is a silent disease with a poor prognosis that urgently require...
International audienceOvarian cancer is a silent disease with a poor prognosis that urgently require...
Low-grade serous ovarian cancer (LGSOC) is a rare subtype of epithelial ovarian cancer with high fat...
Low-grade serous ovarian cancer (LGSOC) is a rare subtype of epithelial ovarian cancer with high fat...
Low-grade serous ovarian cancer (LGSOC) is a rare subtype of epithelial ovarian cancer with high fat...
Low-grade serous ovarian cancer (LGSOC) is a rare subtype of epithelial ovarian cancer with high fat...
Low-grade serous ovarian cancer (LGSOC) is a rare subtype of epithelial ovarian cancer with high fat...
Representing approximately 5% of all epithelial ovarian cancers, low-grade serous ovarian carcinoma ...
Low-grade serous ovarian carcinoma, or LGSOC, predominantly occurs in pre- menopausal women at lower...
Representing approximately 5% of all epithelial ovarian cancers, low-grade serous ovarian carcinoma ...
Background: Although low-grade serous ovarian cancer (LGSC) is rare, case-fatality rates are high as...
Background: Although low-grade serous ovarian cancer (LGSC) is rare, case-fatality ...
Abstract Background Although low-grade serous ovarian cancer (LGSC) is rare, case-fatality rates are...
Background: Although low-grade serous ovarian cancer (LGSC) is rare, case-fatality rates are high as...
International audienceOvarian cancer is a silent disease with a poor prognosis that urgently require...
International audienceOvarian cancer is a silent disease with a poor prognosis that urgently require...
International audienceOvarian cancer is a silent disease with a poor prognosis that urgently require...
Low-grade serous ovarian cancer (LGSOC) is a rare subtype of epithelial ovarian cancer with high fat...
Low-grade serous ovarian cancer (LGSOC) is a rare subtype of epithelial ovarian cancer with high fat...
Low-grade serous ovarian cancer (LGSOC) is a rare subtype of epithelial ovarian cancer with high fat...
Low-grade serous ovarian cancer (LGSOC) is a rare subtype of epithelial ovarian cancer with high fat...
Low-grade serous ovarian cancer (LGSOC) is a rare subtype of epithelial ovarian cancer with high fat...
Representing approximately 5% of all epithelial ovarian cancers, low-grade serous ovarian carcinoma ...
Low-grade serous ovarian carcinoma, or LGSOC, predominantly occurs in pre- menopausal women at lower...
Representing approximately 5% of all epithelial ovarian cancers, low-grade serous ovarian carcinoma ...
Background: Although low-grade serous ovarian cancer (LGSC) is rare, case-fatality rates are high as...
Background: Although low-grade serous ovarian cancer (LGSC) is rare, case-fatality ...
Abstract Background Although low-grade serous ovarian cancer (LGSC) is rare, case-fatality rates are...
Background: Although low-grade serous ovarian cancer (LGSC) is rare, case-fatality rates are high as...
International audienceOvarian cancer is a silent disease with a poor prognosis that urgently require...
International audienceOvarian cancer is a silent disease with a poor prognosis that urgently require...
International audienceOvarian cancer is a silent disease with a poor prognosis that urgently require...