AUROCs of immune and endothelial activation biomarkers and clinical parameters.

(A) IL-8, sFlt-1, sTREM-1, sTNFR1, Angpt-2, PCT, and IL-6 AUROCs for in-hospital deaths (n = 432). (B) IL-8, sFlt-1, sTREM-1, and CRP AUROCs for in-hospital deaths (n = 421). (C) IL-8, sFlt-1, and sTREM-1 AUROCs for 28-day and 90-day mortality (in-hospital & post-discharge) (n = 309). (D) IL-8 and clinical parameters AUROCs for in-hospital deaths (n = 405). Abbreviations: Angpt-2 (angiopoietin-2), AUROC (area under the receiver operating characteristic curve), CRP (C-reactive protein), IL-6 (interleukin-6), IL-8 (interleukin-8), LODS (Lambaréné Organ Dysfunction Score), PCT (procalcitonin), RISC-Malawi (Respiratory Index of Severity in Children-Malawi), sFlt-1 (soluble fms-like tyrosine kinase-1), sTNFR1 (soluble tumor necrosis factor receptor), sTREM-1 (soluble triggering receptor expressed on myeloid cells 1), WHO (World Health Organization).