Therapeutic effect of TAS5315 on bone destruction in a mouse CIA model.
- Daichi Akasaka (14670684)
- Satoru Iguchi (14670687)
- Ryusuke Kaneko (14670690)
- Yohei Yoshiga (111997)
- Daisuke Kajiwara (14670693)
- Yoshinori Nakachi (14670696)
- Naruto Noma (14670699)
- Kenji Tanaka (692662)
- Atsushi Shimizu (1862)
- Fumihito Hosoi (2538544)
Publication date
February 2023
DOI Publisher
Public Library of Science (PLoS)Abstract
(a) Arthritis score of hind paws in a mouse CIA model. Experimental arthritis was induced by two immunizations with collagen and CFA. Mice were administered vehicle, TAS5315, or prednisolone (Pred) once daily for 21 days from the 11th day after the second immunization (day 1). (b) Representative images of the right hind paw obtained by micro-CT on days 1, 8, 14, and 22. (c) The vertical axis depicts BMD values as determined by micro-CT analysis of both hind paws. Data are presented as mean ± SEM (n = 6–12 per group). *PPP<0.001 compared with the vehicle group (Steel test for TAS5315 groups, Wilcoxon test for Pred group).</p
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