DKO mice showed milder phenotypes in HFD-induced body weight gain and hyperglycemia.

(A) Body weights of WT and DKO mice in CD-fed states (WT, n = 7; DKO, n = 6), and (B) HDF-fed states (7 mice each). Body weights recorded every week from 4 to 19 weeks old. Open and closed bars indicate WT and DKO mice, respectively. Data are expressed as means ± S.D. *PC) Blood glucose and serum levels of lipids in CD-fed or HFD-fed mice. Open and closed bars show WT and DKO mice, respectively. Data are expressed as means ± S.D. ***P#P###P<0.001 as compared between CD and HFD groups.