Preoperative predictors for early and very early disease recurrence in patients undergoing resection of pancreatic ductal adenocarcinoma
- Daamen, L.A.
- Dorland, G.
- Brada, L.J.H.
- Groot, V.P.
- Oosten, A.F. van
- Besselink, M.G.
- Bosscha, K.
- Bonsing, B.A.
- Busch, O.R.
- Cirkel, G.A.
- Dam, R.M. van
- Festen, S.
- Koerkamp, B.G.
- Mohammad, N.H.
- Harst, E. van der
- Hingh, I.H.J.T. de
- Intven, M.P.W.
- Kazemier, G.
- Meijer, V.E. de
- Nieuwenhuijs, V.B.
- Roos, D.
- Schreinemakers, J.M.J.
- Stommel, M.W.J.
- Verdonk, R.C.
- Verkooijen, H.M.
- Molenaar, I.Q.
- Santvoort, H.C. van
- Dutch Pancreatic Canc Grp
DOIAbstract
Background: This study aimed to identify predictors for early and very early disease recurrence in patients undergoing resection of pancreatic ductal adenocarcinoma (PDAC) resection with and without neoadjuvant therapy. Methods: Included were patients who underwent PDAC resection (2014-2016). Multivariable multinomial regression was performed to identify preoperative predictors for manifestation of recurrence within 3, 6 and 12 months after PDAC resection. Results: 836 patients with a median follow-up of 37 (interquartile range [IQR] 30-48) months and overall survival of 18 (IQR 10-32) months were analyzed. 670 patients (80%) developed recurrence: 82 patients (10%) 4 (OR 1.53 [95% CI 1.09-2.16]; P = 0.02) and logCA 19-9 (OR 1.24 [95% CI 1....
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