Background: Intrathecal immunoglobulin-G synthesis is a hallmark of multiple sclerosis (MS), which can be detected by oligoclonal IgG bands (OCB) or by κ-free light chains (κ-FLC) in cerebrospinal fluid. Objective: To perform a systematic review and meta-analysis to evaluate whether κ-FLC index has similar diagnostic value to identify patients with clinically isolated syndrome (CIS) or MS compared to OCB, and to determine κ-FLC index cut-off. Methods: PubMed was searched for studies that assessed diagnostic sensitivity and specificity of κ-FLC index and OCB to discriminate CIS/MS patients from control subjects. Two reviewers following preferred reporting items for systematic reviews and meta-analyses (PRISMA) guidelines performed study elig...
Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system. Prev...
The detection of cerebrospinal fluid (CSF)-specific IgG oligoclonal bands (OCB) by isoelectric focus...
Cerebrospinal fluid (CSF) free light kappa chains (kappa FLC) may be a more sensitive marker of intr...
Background: Intrathecal immunoglobulin-G synthesis is a hallmark of multiple sclerosis (MS), which c...
Intrathecal immunoglobulin-G synthesis is a hallmark of multiple sclerosis (MS), which can be detect...
Objectives: The importance of immunoglobulin G (IgG) oligoclonal bands (OCB) in the diagnosis of mul...
Cerebrospinal fluid (CSF) kappa free light chains (KFLC) are gaining increasing interest as markers ...
To validate kappa free light chain (KFLC) and lambda free light chain (LFLC) indices as a diagnostic...
BackgroundKappa free light chains (κ-FLC) in the cerebrospinal fluid (CSF) are an emerging biomarker...
To validate kappa free light chain (KFLC) and lambda free light chain (LFLC) indices as a diagnostic...
Kappa free light chain (KFLC)-index, a measure for intrathecal production of free kappa chains, has ...
Introduction. Mulple Sclerosis (MS) cerebrospinal fluid (CSF) hallmarks are increased intrathecal i...
BACKGROUND: Oligoclonal bands (OCB) are the most widely used CSF test to support the diagnosis of MS...
Cerebrospinal fluid (CSF) kappa free light chain (KFLC) index has been described as a reliable marke...
Cerebrospinal fluid (CSF) free light chains (FLC) may be an alternative biomarker to oligoclonal ban...
Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system. Prev...
The detection of cerebrospinal fluid (CSF)-specific IgG oligoclonal bands (OCB) by isoelectric focus...
Cerebrospinal fluid (CSF) free light kappa chains (kappa FLC) may be a more sensitive marker of intr...
Background: Intrathecal immunoglobulin-G synthesis is a hallmark of multiple sclerosis (MS), which c...
Intrathecal immunoglobulin-G synthesis is a hallmark of multiple sclerosis (MS), which can be detect...
Objectives: The importance of immunoglobulin G (IgG) oligoclonal bands (OCB) in the diagnosis of mul...
Cerebrospinal fluid (CSF) kappa free light chains (KFLC) are gaining increasing interest as markers ...
To validate kappa free light chain (KFLC) and lambda free light chain (LFLC) indices as a diagnostic...
BackgroundKappa free light chains (κ-FLC) in the cerebrospinal fluid (CSF) are an emerging biomarker...
To validate kappa free light chain (KFLC) and lambda free light chain (LFLC) indices as a diagnostic...
Kappa free light chain (KFLC)-index, a measure for intrathecal production of free kappa chains, has ...
Introduction. Mulple Sclerosis (MS) cerebrospinal fluid (CSF) hallmarks are increased intrathecal i...
BACKGROUND: Oligoclonal bands (OCB) are the most widely used CSF test to support the diagnosis of MS...
Cerebrospinal fluid (CSF) kappa free light chain (KFLC) index has been described as a reliable marke...
Cerebrospinal fluid (CSF) free light chains (FLC) may be an alternative biomarker to oligoclonal ban...
Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system. Prev...
The detection of cerebrospinal fluid (CSF)-specific IgG oligoclonal bands (OCB) by isoelectric focus...
Cerebrospinal fluid (CSF) free light kappa chains (kappa FLC) may be a more sensitive marker of intr...