Exploring water, sanitation, and hygiene coverage targets for reaching and sustaining trachoma elimination: G-computation analysis.
- Sullivan, Kristin M
- Harding-Esch, Emma M
- Keil, Alexander P
- Freeman, Matthew C
- Batcho, Wilfrid E
- Bio Issifou, Amadou A
- Bucumi, Victor
- Bella, Assumpta L
- Epee, Emilienne
- Bobo Barkesa, Segni
- Seife Gebretsadik, Fikre
- Sanha, Salimato
- Kalua, Khumbo M
- Masika, Michael P
- Minnih, Abdallahi O
- Abdala, Mariamo
- Massangaie, Marília E
- Amza, Abdou
- Kadri, Boubacar
- Nassirou, Beido
- Mpyet, Caleb D
- Olobio, Nicholas
- Badiane, Mouctar D
- Elshafie, Balgesa E
- Baayenda, Gilbert
- Kabona, George E
- Kaitaba, Oscar
- Simon, Alistidia
- Al-Khateeb, Tawfik Q
- Mwale, Consity
- Bakhtiari, Ana
- Westreich, Daniel
- Solomon, Anthony W
- Gower, Emily W
DOIAbstract
BACKGROUND: Trachoma is the leading infectious cause of blindness. To reduce transmission, water, sanitation, and hygiene (WaSH) improvements are promoted through a comprehensive public health strategy. Evidence supporting the role of WaSH in trachoma elimination is mixed and it remains unknown what WaSH coverages are needed to effectively reduce transmission. METHODS/FINDINGS: We used g-computation to estimate the impact on the prevalence of trachomatous inflammation-follicular among children aged 1-9 years (TF1-9) when hypothetical WaSH interventions raised the minimum coverages from 5% to 100% for "nearby" face-washing water (<30 minutes roundtrip collection time) and adult latrine use in an evaluation unit (EU). For each scenario, we es...
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