Incorporating genetics into risk-stratification for treatment of childhood B-progenitor acute lymphoblastic leukaemia (B-ALL) has contributed significantly to improved survival. In about 30% B-ALL (B-other-ALL) without well-established chromosomal changes, new genetic subtypes have recently emerged, yet their true prognostic relevance largely remains unclear. We integrated next generation sequencing (NGS): whole genome sequencing (WGS) (n = 157) and bespoke targeted NGS (t-NGS) (n = 175) (overlap n = 36), with existing genetic annotation in a representative cohort of 351 B-other-ALL patients from the childhood ALL trail, UKALL2003. PAX5alt was most frequently observed (n = 91), whereas PAX5 P80R mutations (n = 11) defined a distinct PAX5 su...
Acute lymphoblastic leukaemia (ALL) is a heterogeneous disease at the cytogenetic and molecular gene...
Genomic studies of pediatric acute lymphoblastic leukemia (ALL) have shown remarkable heterogeneity ...
Identifying additional genetic alterations associated with poor prognosis in acute lymphoblastic leu...
Background Genetic subtypes of acute lymphoblastic leukaemia (ALL) are used to determine risk and tr...
Background: Genetic subtypes of acute lymphoblastic leukaemia (ALL) are used to determine risk and t...
There is increasing evidence for a strong inherited genetic basis of susceptibility to acute lymphob...
Recent genomic studies have provided a refined genetic map of acute lymphoblastic leukemia (ALL) and...
Somatic genetic abnormalities are initiators and drivers of disease and have proven clinical utility...
Somatic genetic abnormalities are initiators and drivers of disease and have proven clinical utility...
Genomic classification has improved risk assignment of pediatric but not adult B-lineage acute lymph...
Acute lymphoblastic leukaemia (ALL) is the commonest childhood cancer and an important cause of morb...
Childhood acute lymphoblastic leukemia (ALL) is the most common form of childhood cancer today. Due...
Acute lymphoblastic leukemia (ALL) is the most common childhood cancer and accounts for about a quar...
B-precursor acute lymphoblastic leukemia (B-ALL) is the most common childhood tumor and the leading ...
Acute lymphoblastic leukemia (ALL) is the most frequent malignant disease in the pediatric populatio...
Acute lymphoblastic leukaemia (ALL) is a heterogeneous disease at the cytogenetic and molecular gene...
Genomic studies of pediatric acute lymphoblastic leukemia (ALL) have shown remarkable heterogeneity ...
Identifying additional genetic alterations associated with poor prognosis in acute lymphoblastic leu...
Background Genetic subtypes of acute lymphoblastic leukaemia (ALL) are used to determine risk and tr...
Background: Genetic subtypes of acute lymphoblastic leukaemia (ALL) are used to determine risk and t...
There is increasing evidence for a strong inherited genetic basis of susceptibility to acute lymphob...
Recent genomic studies have provided a refined genetic map of acute lymphoblastic leukemia (ALL) and...
Somatic genetic abnormalities are initiators and drivers of disease and have proven clinical utility...
Somatic genetic abnormalities are initiators and drivers of disease and have proven clinical utility...
Genomic classification has improved risk assignment of pediatric but not adult B-lineage acute lymph...
Acute lymphoblastic leukaemia (ALL) is the commonest childhood cancer and an important cause of morb...
Childhood acute lymphoblastic leukemia (ALL) is the most common form of childhood cancer today. Due...
Acute lymphoblastic leukemia (ALL) is the most common childhood cancer and accounts for about a quar...
B-precursor acute lymphoblastic leukemia (B-ALL) is the most common childhood tumor and the leading ...
Acute lymphoblastic leukemia (ALL) is the most frequent malignant disease in the pediatric populatio...
Acute lymphoblastic leukaemia (ALL) is a heterogeneous disease at the cytogenetic and molecular gene...
Genomic studies of pediatric acute lymphoblastic leukemia (ALL) have shown remarkable heterogeneity ...
Identifying additional genetic alterations associated with poor prognosis in acute lymphoblastic leu...