Human scattered tubular cells represent a heterogeneous population of glycolytic dedifferentiated proximal tubule cells
- Eymael, Jennifer
- van den Broek, Martijn
- Miesen, Laura
- Monge, Valerie Villacorta
- van den Berge, Bartholomeus T.
- Mooren, Fieke
- Velez, Vicky Luna
- Dijkstra, Jelmer
- Hermsen, Meyke
- Bándi, Péter
- Vermeulen, Michiel
- de Wildt, Saskia
- Willemsen, Brigith
- Florquin, Sandrine
- Wetzels, Roy
- Steenbergen, Eric
- Kramann, Rafael
- Moeller, Marcus
- Schreuder, Michiel F.
- Wetzels, Jack F.M.
- van der Vlag, Johan
- Jansen, Jitske
- Smeets, Bart
DOIAbstract
Scattered tubular cells (STCs) are a phenotypically distinct cell population in the proximal tubule that increase in number after acute kidney injury. We aimed to characterize the human STC population. Three-dimensional human tissue analysis revealed that STCs are preferentially located within inner bends of the tubule and are barely present in young kidney tissue (<2 years), and their number increases with age. Increased STC numbers were associated with acute tubular injury (kidney injury molecule 1) and interstitial fibrosis (alpha smooth muscle actin). Isolated CD13+CD24−CD133− proximal tubule epithelial cells (PTECs) and CD13+CD24+ and CD13+CD133+ STCs were analyzed using RNA sequencing. Transcriptome analysis revealed an upregulation o...
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