The PDB IDs of each BCL-2:BH3 interaction is listed next to the binding pattern variation it corresponds to. Less common residues are shown in parentheses. Two-dimensional lattice of BH3 helix is shown in top left, with knob residues that pack into BCL-2 protein outlined in purple. (TIFF)</p
<p>Binding profiles for known BH3 peptides interacting with Bcl-x<sub>L</sub>, Bcl-w, Bcl-2, Mcl-1 a...
B-cell lymphoma-2 (Bcl-2) proteins mediate intrinsic-, or mitochondrial-, initiated apoptosis. We ha...
Interactions between Bcl-2-like proteins and BH3 domains play a key role in the regulation of apopto...
The PDB IDs of each BCL-2:BH3 interaction is listed next to the binding pattern variation it corresp...
For each highlighted conserved residue, indicated is the pocket(s) in which it binds into on the Bcl...
Cancer cells bypass cell death by changing the expression of the BCL-2 family of proteins, which are...
The recognition of helical BH3 domains by Bcl-2 homology (BH) receptors plays a central role in apop...
Bcl-XL is a member of Bcl-2 family of proteins involved in the regulation of intrinsic pathway of ap...
<p>(a) A predicted three dimensional structure of the HsBNIP-2 BCH domain is displayed in this figur...
The BCL-2 family of proteins plays a central role in regulating cell survival and apoptosis. Disorde...
Interactions among Bcl-2 family proteins are important for regulating apoptosis. Pro-survival member...
The bZIP transcription factors make up a family of long α-helical proteins that dimerize based on a ...
Cancer has been a pervasive and deadly problem for many years. So far, no treatments have been devel...
(A-D) Selection of representative ligand helices from pro-survival protein-BH3 domain complexes. (A)...
<p>The sequence logos derived from 175 BCH and 78 CRAL_TRIO domain sequences are shown in this figur...
<p>Binding profiles for known BH3 peptides interacting with Bcl-x<sub>L</sub>, Bcl-w, Bcl-2, Mcl-1 a...
B-cell lymphoma-2 (Bcl-2) proteins mediate intrinsic-, or mitochondrial-, initiated apoptosis. We ha...
Interactions between Bcl-2-like proteins and BH3 domains play a key role in the regulation of apopto...
The PDB IDs of each BCL-2:BH3 interaction is listed next to the binding pattern variation it corresp...
For each highlighted conserved residue, indicated is the pocket(s) in which it binds into on the Bcl...
Cancer cells bypass cell death by changing the expression of the BCL-2 family of proteins, which are...
The recognition of helical BH3 domains by Bcl-2 homology (BH) receptors plays a central role in apop...
Bcl-XL is a member of Bcl-2 family of proteins involved in the regulation of intrinsic pathway of ap...
<p>(a) A predicted three dimensional structure of the HsBNIP-2 BCH domain is displayed in this figur...
The BCL-2 family of proteins plays a central role in regulating cell survival and apoptosis. Disorde...
Interactions among Bcl-2 family proteins are important for regulating apoptosis. Pro-survival member...
The bZIP transcription factors make up a family of long α-helical proteins that dimerize based on a ...
Cancer has been a pervasive and deadly problem for many years. So far, no treatments have been devel...
(A-D) Selection of representative ligand helices from pro-survival protein-BH3 domain complexes. (A)...
<p>The sequence logos derived from 175 BCH and 78 CRAL_TRIO domain sequences are shown in this figur...
<p>Binding profiles for known BH3 peptides interacting with Bcl-x<sub>L</sub>, Bcl-w, Bcl-2, Mcl-1 a...
B-cell lymphoma-2 (Bcl-2) proteins mediate intrinsic-, or mitochondrial-, initiated apoptosis. We ha...
Interactions between Bcl-2-like proteins and BH3 domains play a key role in the regulation of apopto...