The PDB IDs of each BCL-2:BH3 interaction is listed next to the binding pattern variation it corresponds to. Less common residues are shown in parentheses. Two-dimensional lattice of BH3 helix is shown in top left, with knob residues that pack into BCL-2 protein outlined in purple. (TIFF)</p
Interactions among Bcl-2 family proteins are important for regulating apoptosis. Pro-survival member...
bZIP transcription factors make up a family of long α-helical proteins that dimerize and bind to DNA...
Basic leucine zipper domain (bZIP) transcription factors are proteins that dimerize to bind the prom...
The PDB IDs of each BCL-2:BH3 interaction is listed next to the binding pattern variation it corresp...
For each highlighted conserved residue, indicated is the pocket(s) in which it binds into on the Bcl...
Cancer cells bypass cell death by changing the expression of the BCL-2 family of proteins, which are...
Bcl-XL is a member of Bcl-2 family of proteins involved in the regulation of intrinsic pathway of ap...
The recognition of helical BH3 domains by Bcl-2 homology (BH) receptors plays a central role in apop...
Cancer has been a pervasive and deadly problem for many years. So far, no treatments have been devel...
<p>(a) A predicted three dimensional structure of the HsBNIP-2 BCH domain is displayed in this figur...
The bZIP transcription factors make up a family of long α-helical proteins that dimerize based on a ...
The BCL-2 family of proteins plays a central role in regulating cell survival and apoptosis. Disorde...
(A-D) Selection of representative ligand helices from pro-survival protein-BH3 domain complexes. (A)...
<p>Binding profiles for known BH3 peptides interacting with Bcl-x<sub>L</sub>, Bcl-w, Bcl-2, Mcl-1 a...
<p>Helix 3 that moves upon ligand binding is coloured differently for the ligand-bound structures (1...
Interactions among Bcl-2 family proteins are important for regulating apoptosis. Pro-survival member...
bZIP transcription factors make up a family of long α-helical proteins that dimerize and bind to DNA...
Basic leucine zipper domain (bZIP) transcription factors are proteins that dimerize to bind the prom...
The PDB IDs of each BCL-2:BH3 interaction is listed next to the binding pattern variation it corresp...
For each highlighted conserved residue, indicated is the pocket(s) in which it binds into on the Bcl...
Cancer cells bypass cell death by changing the expression of the BCL-2 family of proteins, which are...
Bcl-XL is a member of Bcl-2 family of proteins involved in the regulation of intrinsic pathway of ap...
The recognition of helical BH3 domains by Bcl-2 homology (BH) receptors plays a central role in apop...
Cancer has been a pervasive and deadly problem for many years. So far, no treatments have been devel...
<p>(a) A predicted three dimensional structure of the HsBNIP-2 BCH domain is displayed in this figur...
The bZIP transcription factors make up a family of long α-helical proteins that dimerize based on a ...
The BCL-2 family of proteins plays a central role in regulating cell survival and apoptosis. Disorde...
(A-D) Selection of representative ligand helices from pro-survival protein-BH3 domain complexes. (A)...
<p>Binding profiles for known BH3 peptides interacting with Bcl-x<sub>L</sub>, Bcl-w, Bcl-2, Mcl-1 a...
<p>Helix 3 that moves upon ligand binding is coloured differently for the ligand-bound structures (1...
Interactions among Bcl-2 family proteins are important for regulating apoptosis. Pro-survival member...
bZIP transcription factors make up a family of long α-helical proteins that dimerize and bind to DNA...
Basic leucine zipper domain (bZIP) transcription factors are proteins that dimerize to bind the prom...