Representative AP traces before and 15 to 30 mins after drug exposure at indicated concentration (top) and automatically quantified AP metrics from microtissues containing 5% hCF after 6~8 days in culture (bottom). (A) Tetrodotoxin (TTX, 1 μM), a selective Na+ channel blocker, increased stimulation delay and rise time and moderately increased APD80 and APDmxr (n = 32 microtissues). (B) Flecainide (20 μM), a INa and IKr blocker, increased stimulation delay and rise time as well as APD30, APD50, APD80, APDmxr, and APDtri (n = 35 microtissues). The increase ion APDtri is caused by larger prolongation of APDmxr compared APD30 and APD50. (C) Nifedipine (2 μM), a selective L-type Ca2+ channel blocker, shortened APD30, APD50, APD80, APDmxr, and AP...
<p>I<sub>to</sub>–: I<sub>to</sub> blocked by 500 nM nicotine; I<sub>Kur.d</sub>–: I<sub>Kur.d</sub>...
<p>(A) The representative <i>I</i><sub>Na</sub> tracings obtained by the pulse protocol shown in the...
Several false-positive results in the human ether-à-gogo-related gene test suggest that blockers of ...
(A) Human action potential model by O’Hara et al. [52] and the underlying major ionic currents: Na+ ...
<p>Relative FPD values were obtained with the MEA system on Day 2 to Day 6 for each colony in the pr...
<p>Cell Index (CI) data generated by Xcelligence RTCA when serum starved HL-1 cells were treated wit...
Comparisons of IC50 values for CaV1.2 channel block for methadone, diltiazem, and verapamil generate...
Preclinical assessment of drug-induced proarrhythmicity is typically evaluated by the potency of the...
<p>Simulated blockade of the sodium currents via TTX (B) and of IK<sub>1</sub> current via barium ch...
Introduction: unwanted drug interactions with ionic currents in the heart can lead to an increased p...
Results are reported as mean +/- standard deviation (percent change of mean from cell mean without c...
Introduction: Unwanted drug interactions with ionic currents in the heart can lead to an increased p...
<p>(a) Single channel current recordings of the Na<sub>v</sub>Sp pore for different concentration of...
noEvaluation of drug candidates in in-vitro assays of action potential duration (APD) is one compone...
AbstractIntroductionUnwanted drug interactions with ionic currents in the heart can lead to an incre...
<p>I<sub>to</sub>–: I<sub>to</sub> blocked by 500 nM nicotine; I<sub>Kur.d</sub>–: I<sub>Kur.d</sub>...
<p>(A) The representative <i>I</i><sub>Na</sub> tracings obtained by the pulse protocol shown in the...
Several false-positive results in the human ether-à-gogo-related gene test suggest that blockers of ...
(A) Human action potential model by O’Hara et al. [52] and the underlying major ionic currents: Na+ ...
<p>Relative FPD values were obtained with the MEA system on Day 2 to Day 6 for each colony in the pr...
<p>Cell Index (CI) data generated by Xcelligence RTCA when serum starved HL-1 cells were treated wit...
Comparisons of IC50 values for CaV1.2 channel block for methadone, diltiazem, and verapamil generate...
Preclinical assessment of drug-induced proarrhythmicity is typically evaluated by the potency of the...
<p>Simulated blockade of the sodium currents via TTX (B) and of IK<sub>1</sub> current via barium ch...
Introduction: unwanted drug interactions with ionic currents in the heart can lead to an increased p...
Results are reported as mean +/- standard deviation (percent change of mean from cell mean without c...
Introduction: Unwanted drug interactions with ionic currents in the heart can lead to an increased p...
<p>(a) Single channel current recordings of the Na<sub>v</sub>Sp pore for different concentration of...
noEvaluation of drug candidates in in-vitro assays of action potential duration (APD) is one compone...
AbstractIntroductionUnwanted drug interactions with ionic currents in the heart can lead to an incre...
<p>I<sub>to</sub>–: I<sub>to</sub> blocked by 500 nM nicotine; I<sub>Kur.d</sub>–: I<sub>Kur.d</sub>...
<p>(A) The representative <i>I</i><sub>Na</sub> tracings obtained by the pulse protocol shown in the...
Several false-positive results in the human ether-à-gogo-related gene test suggest that blockers of ...