The unique insertion in ANK domain mediates higher-order structure formation and directly contact the substrate.
- Damu Wu (14253263)
- Yan Liu (25061)
- Yuhao Dai (6663512)
- Guopeng Wang (720360)
- Guoliang Lu (443188)
- Yan Chen (4308)
- Ningning Li (566420)
- Jinzhong Lin (189430)
- Ning Gao (153779)
Publication date
February 2023
DOI Publisher
Public Library of Science (PLoS)Abstract
(A) Residual densities around the ANK domains, extending towards the central channel of the CLPBE425Q complex in the substrate-bound state. The extra densities are highlighted by a dotted ellipse. The density of the substrate is shown in yellow. (B) SDS-PAGE analysis of the purified proteins. (C–E) Purification of CLPB, CLPBΔ201–232, and CLPBisoform1 complexes using size-exclusion chromatography. (TIF)</p
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