Iatrogenic hypoglycaemia activates the immune system and is associated with an increased risk for atherosclerotic disease. We determined acute and long-term effects of insulin-induced hypoglycemia on inflammatory markers in humans with or without type 2 diabetes. Fifteen adults with type 2 diabetes and 16 matched controls (M/F 17/14, age 59.6±7.1 years, BMI 28.5±4.3 kg/m2) underwent a hyperinsulinemic-euglycemic (5.31±0.32 mmol/L) hypoglycemic (2.80±0.12 mmol/L) glucose clamp. Blood was drawn during euglycemia and hypoglycemia and 1, 3 and 7 days later, to determine circulating immune cell composition, function, and inflammatory proteins. In response to hypoglycemia, absolute numbers of circulating lymphocytes and monocytes significantly in...
This study aims to assess the proinflammatory interleukin 1β (IL-1β) and anti-inflammatory IL-10 pro...
Abstract Heat shock proteins contribute to diabetes-induced complications and are affected by glycem...
Objective: Higher systemic levels of proinflammatory biomarkers and low adiponectin are associated w...
Iatrogenic hypoglycaemia activates the immune system and is associated with an increased risk for at...
Iatrogenic hypoglycemia activates the immune system and is associated with an increased risk for ath...
Item does not contain fulltextSevere hypoglycemic events have been associated with increased cardiov...
Severe hypoglycemic events have been associated with increased cardiovascular mortality in patients ...
Aim: To determine the duration and the extension of the pro-inflammatory response to hypoglycaemia b...
Intensive diabetes control has been associated with increased mortality in type 2 diabetes (T2DM); t...
Intensive diabetes control has been associated with increased mortality in type 2 diabetes (T2DM); t...
Aim: To investigate whether a history of severe hypoglycaemia (SH) or the associated presence of imp...
Hypoglycaemia is associated with cardiovascular (CV) events in diabetes. The mechanisms through whic...
AIMS: Type 2 diabetes is frequently associated with infectious complications. Swift activation of le...
This study aims to assess the proinflammatory interleukin 1β (IL-1β) and anti-inflammatory IL-10 pro...
Abstract Heat shock proteins contribute to diabetes-induced complications and are affected by glycem...
Objective: Higher systemic levels of proinflammatory biomarkers and low adiponectin are associated w...
Iatrogenic hypoglycaemia activates the immune system and is associated with an increased risk for at...
Iatrogenic hypoglycemia activates the immune system and is associated with an increased risk for ath...
Item does not contain fulltextSevere hypoglycemic events have been associated with increased cardiov...
Severe hypoglycemic events have been associated with increased cardiovascular mortality in patients ...
Aim: To determine the duration and the extension of the pro-inflammatory response to hypoglycaemia b...
Intensive diabetes control has been associated with increased mortality in type 2 diabetes (T2DM); t...
Intensive diabetes control has been associated with increased mortality in type 2 diabetes (T2DM); t...
Aim: To investigate whether a history of severe hypoglycaemia (SH) or the associated presence of imp...
Hypoglycaemia is associated with cardiovascular (CV) events in diabetes. The mechanisms through whic...
AIMS: Type 2 diabetes is frequently associated with infectious complications. Swift activation of le...
This study aims to assess the proinflammatory interleukin 1β (IL-1β) and anti-inflammatory IL-10 pro...
Abstract Heat shock proteins contribute to diabetes-induced complications and are affected by glycem...
Objective: Higher systemic levels of proinflammatory biomarkers and low adiponectin are associated w...