ErbB2 overexpression is detected in approximately 20% of breast cancers and is correlated with poor survival. It was previously shown that the adaptor protein p130Cas/BCAR1 is a crucial mediator of ErbB2 transformation and that its overexpression confers invasive properties to ErbB2-positive human mammary epithelial cells. We herein prove, for the first time, that the transcriptional repressor Blimp1 is a novel mediator of p130Cas/ErbB2-mediated invasiveness. Indeed, high Blimp1 expression levels are detected in invasive p130Cas/ErbB2 cells and correlate with metastatic status in human breast cancer patients. The present study, by using 2D and 3D breast cancer models, shows that the increased Blimp1 expression depends on both MAPK activatio...
Mammary gland morphogenesis depends on a tight balance between cell proliferation, differentiation a...
Identification of genes that are upregulated during mammary epithelial cell morphogenesis may reveal...
Breast cancer (BC) is the most common malignancy and the leading cause of death in women worldwide. ...
Understanding transcriptional changes during cancer progression is of crucial importance to develop ...
ErbB2 over-expression is detected in approximately 25\% of invasive breast cancers and is strongly a...
ErbB2 over-expression is detected in approximately 25% of invasive breast cancers and is strongly as...
Understanding transcriptional changes during cancer progression is of crucial importance to develop ...
The ErbB2 oncogene is often overexpressed in breast tumors and associated with poor clinical outcome...
SummaryErbB2, a metastasis-promoting oncoprotein, is overexpressed in ∼25% of invasive/metastatic br...
Backgound: The human ERBB2 gene is frequently amplified in breast tumors, and its high expression is...
The ErbB2 oncogene is often overexpressed in breast tumors and associated with poor clinical outcome...
International audienceAberrant constitutive expression of NF-kappaB subunits, reported in more than ...
The docking protein p140Cap negatively regulates tumour cell features. Its relevance on breast canc...
Mammary gland morphogenesis depends on a tight balance between cell proliferation, differentiation a...
Identification of genes that are upregulated during mammary epithelial cell morphogenesis may reveal...
Breast cancer (BC) is the most common malignancy and the leading cause of death in women worldwide. ...
Understanding transcriptional changes during cancer progression is of crucial importance to develop ...
ErbB2 over-expression is detected in approximately 25\% of invasive breast cancers and is strongly a...
ErbB2 over-expression is detected in approximately 25% of invasive breast cancers and is strongly as...
Understanding transcriptional changes during cancer progression is of crucial importance to develop ...
The ErbB2 oncogene is often overexpressed in breast tumors and associated with poor clinical outcome...
SummaryErbB2, a metastasis-promoting oncoprotein, is overexpressed in ∼25% of invasive/metastatic br...
Backgound: The human ERBB2 gene is frequently amplified in breast tumors, and its high expression is...
The ErbB2 oncogene is often overexpressed in breast tumors and associated with poor clinical outcome...
International audienceAberrant constitutive expression of NF-kappaB subunits, reported in more than ...
The docking protein p140Cap negatively regulates tumour cell features. Its relevance on breast canc...
Mammary gland morphogenesis depends on a tight balance between cell proliferation, differentiation a...
Identification of genes that are upregulated during mammary epithelial cell morphogenesis may reveal...
Breast cancer (BC) is the most common malignancy and the leading cause of death in women worldwide. ...