The mechanisms driving the Atlantic meridional overturning circulation (AMOC) low-frequency variability and the climate impact are investigated in the atmosphere-ocean coupled general circulation model (AOGCM) IPSL-CM6A-LR. A centennial to multi-centennial variability of the AMOC emerges in this model, which increases the uncertainties associated with internal variability in the climate projections. We isolate the low-frequency variations in a 2000- yr preindustrial control simulation and show the dominant role of the freshwater exchanges between the Arctic Ocean and the North Atlantic in controlling the AMOC intensity.As the AMOC increases, the ocean transports heat northward, which leads to the sea-ice melting in the Arctic Ocean. Combine...