Inflammation is a hallmark of aging and is negatively affecting female fertility. In this study, we evaluate the role of the NLRP3 inflammasome in ovarian aging and female fertility. Age-dependent increased expression of NLRP3 in the ovary was observed in WT mice during reproductive aging. High expression of NLRP3, caspase-1, and IL-1β was also observed in granulosa cells from patients with ovarian insufficiency. Ablation of NLRP3 improved the survival and pregnancy rates and increased anti-Müllerian hormone levels and autophagy rates in ovaries. Deficiency of NLRP3 also reduced serum FSH and estradiol levels. Consistent with these results, pharmacological inhibition of NLRP3 using a direct NLRP3 inhibitor, MCC950, improved fertility in fem...
Obesity leads to ovarian dysfunction and the establishment of local leptin resistance. The aim of ou...
Neonatal immune challenge by administration of lipopolysaccharide (LPS) produces enduring alteration...
The respiratory system was primarily considered the only organ affected by Coronavirus disease 2019 ...
Inflammation is a hallmark of aging and is negatively affecting female fertility. In this study, we ...
Nucleotide-binding domain and leucine-rich repeat (NLR) proteins are well-known for their key roles ...
The NLRP3 inflammasome has emerged as an important regulator of metabolic disorders and age-related ...
Inflammation is a hallmark of aging and accelerated aging syndromes such as Hutchinson-Gilford proge...
While NLRP3-inflammasome has been implicated in cardiovascular diseases, its role in physiological c...
SummaryDespite a wealth of clinical data showing an association between inflammation and degenerativ...
Inflammation is a hallmark of aging and accelerated aging syndromes such as Hutchinson-Gilford proge...
Abstract Inflammation is a hallmark of aging and accelerated aging syndromes such as Hutchinson–Gilf...
Inflammation is a hallmark of aging and accelerated aging syndromes such as Hutchinson–Gilford proge...
Osteoarthritis (OA), characterized by chronic systemic low-level inflammation and cartilage degenera...
Objective: The activation of the NLRP3 inflammasome has been implicated in male infertility. Our stu...
The normal function of ovaries, along with the secretion of sex hormones, is among the most importan...
Obesity leads to ovarian dysfunction and the establishment of local leptin resistance. The aim of ou...
Neonatal immune challenge by administration of lipopolysaccharide (LPS) produces enduring alteration...
The respiratory system was primarily considered the only organ affected by Coronavirus disease 2019 ...
Inflammation is a hallmark of aging and is negatively affecting female fertility. In this study, we ...
Nucleotide-binding domain and leucine-rich repeat (NLR) proteins are well-known for their key roles ...
The NLRP3 inflammasome has emerged as an important regulator of metabolic disorders and age-related ...
Inflammation is a hallmark of aging and accelerated aging syndromes such as Hutchinson-Gilford proge...
While NLRP3-inflammasome has been implicated in cardiovascular diseases, its role in physiological c...
SummaryDespite a wealth of clinical data showing an association between inflammation and degenerativ...
Inflammation is a hallmark of aging and accelerated aging syndromes such as Hutchinson-Gilford proge...
Abstract Inflammation is a hallmark of aging and accelerated aging syndromes such as Hutchinson–Gilf...
Inflammation is a hallmark of aging and accelerated aging syndromes such as Hutchinson–Gilford proge...
Osteoarthritis (OA), characterized by chronic systemic low-level inflammation and cartilage degenera...
Objective: The activation of the NLRP3 inflammasome has been implicated in male infertility. Our stu...
The normal function of ovaries, along with the secretion of sex hormones, is among the most importan...
Obesity leads to ovarian dysfunction and the establishment of local leptin resistance. The aim of ou...
Neonatal immune challenge by administration of lipopolysaccharide (LPS) produces enduring alteration...
The respiratory system was primarily considered the only organ affected by Coronavirus disease 2019 ...