Mycobacterium tuberculosis Acquires Limited Genetic Diversity in Prolonged Infections, Reactivations and Transmissions Involving Multiple Hosts
- Herranz, Marta
- Pole, Ilva
- Ozere, Iveta
- Chiner-Oms, Alvaro
- Martinez-Lirola, Miguel
- Perez-Garcia, Felipe
- Gijon, Paloma
- Ruiz Serrano, Maria Jesus
- Clotet Romero, Laura
- Cuevas, Oscar
- Comas, Inaki
- Bouza, Emilio
- Perez-Lago, Laura
- Garcia-de-Viedma, Dario
Publication date
January 2018
DOI Publisher
Frontiers media sa Journal
Frontiers in MicrobiologyAbstract
Background: Mycobacterium tuberculosis (MTB) has limited ability to acquire variability. Analysis of its microevolution might help us to evaluate the pathways followed to acquire greater infective success. Whole-genome sequencing (WGS) in the analysis of the transmission of MTB has elucidated the magnitude of variability in MTB. Analysis of transmission currently depends on the identification of clusters, according to the threshold of variability
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