Cell cycle progression is highly regulated by modulating the phosphorylation status of the retinoblastoma protein (pRB) and the other two members of the RB family, p107 and p130. This process is controlled by a balance in the action of kinases, such as the complexes formed by cyclin-dependent kinases (CDKs) and cyclins, and phosphatases, mainly the protein phosphatase 1 (PP1). However, while the phosphorylation of the RB family has been largely studied, its dephosphorylation is less known. Phosphatases are holoenzymes formed by a catalytic subunit and a regulatory protein with substrate specificity. Recently, the PP1-Spinophilin (SPN) holoenzyme has been described as the main phosphatase responsible for the dephosphorylation of RB proteins ...
Protein serine/threonine phosphatases are enzymes that reverse the actions of protein kinases by cle...
Protein phosphorylation is a key mechanism by which normal and cancer cells regulate their main tran...
Free to read on publisher website Eukaryotic cell cycle progression is mediated by phosphorylation o...
Cell cycle progression is highly regulated by modulating the phosphorylation status of the retinobla...
Cell cycle progression is highly regulated by modulating the phosphorylation status of the retinobl...
The family of Retinoblastoma/pocket proteins is one of the master regulators of the eukaryotic cell ...
Rationale: SPINOPHILIN (SPN, PPP1R9B) is an important tumor suppressor involved in the progression a...
AbstractBackground: The retinoblastoma protein (Rb) needs to be phosphorylated by cyclin-dependent k...
[Rationale] SPINOPHILIN (SPN, PPP1R9B) is an important tumor suppressor involved in the progression ...
The phosphorylation state and corresponding activity of the retinoblastoma tumor suppressor protein ...
p105-RB is the product of the retinoblastoma tumor suppressor gene. It is a nuclear phosphoprotein h...
The phosphorylation state and corresponding activity of the retinoblastoma tumor suppressor protein ...
The Rb protein is a tumor suppressor, which plays a pivotal role in the negative control of the cell...
Protein phosphatase-1 (PP-1) was initially identified, purified and characterized as an enzyme invol...
The proteins of the retinoblastoma family are potent inhibitors of cell cycle progression. It is wel...
Protein serine/threonine phosphatases are enzymes that reverse the actions of protein kinases by cle...
Protein phosphorylation is a key mechanism by which normal and cancer cells regulate their main tran...
Free to read on publisher website Eukaryotic cell cycle progression is mediated by phosphorylation o...
Cell cycle progression is highly regulated by modulating the phosphorylation status of the retinobla...
Cell cycle progression is highly regulated by modulating the phosphorylation status of the retinobl...
The family of Retinoblastoma/pocket proteins is one of the master regulators of the eukaryotic cell ...
Rationale: SPINOPHILIN (SPN, PPP1R9B) is an important tumor suppressor involved in the progression a...
AbstractBackground: The retinoblastoma protein (Rb) needs to be phosphorylated by cyclin-dependent k...
[Rationale] SPINOPHILIN (SPN, PPP1R9B) is an important tumor suppressor involved in the progression ...
The phosphorylation state and corresponding activity of the retinoblastoma tumor suppressor protein ...
p105-RB is the product of the retinoblastoma tumor suppressor gene. It is a nuclear phosphoprotein h...
The phosphorylation state and corresponding activity of the retinoblastoma tumor suppressor protein ...
The Rb protein is a tumor suppressor, which plays a pivotal role in the negative control of the cell...
Protein phosphatase-1 (PP-1) was initially identified, purified and characterized as an enzyme invol...
The proteins of the retinoblastoma family are potent inhibitors of cell cycle progression. It is wel...
Protein serine/threonine phosphatases are enzymes that reverse the actions of protein kinases by cle...
Protein phosphorylation is a key mechanism by which normal and cancer cells regulate their main tran...
Free to read on publisher website Eukaryotic cell cycle progression is mediated by phosphorylation o...