Individual genetic background together with environmental effects are thought to be behind many human complex diseases. A number of genetic variants, mainly single nucleotide polymorphisms (SNPs), have been shown to be associated with various pathological and inflammatory conditions, representing potential therapeutic targets. Prostaglandins (PTGs) and leukotrienes (LTs) are eicosanoids derived from arachidonic acid and related polyunsaturated fatty acids that participate in both normal homeostasis and inflammatory conditions. These bioactive lipid mediators are synthesized through two major multistep enzymatic pathways: PTGs by cyclooxygenase and LTs by 5-lipoxygenase. The main physiological effects of PTGs include vasodilation and vascula...
Activation of the prostaglandin D2 receptor (PTGDR) may contribute to pulmonary vasodilation, bronch...
AbstractLeukotrienes (LTs), both LTB4 and the cysteinyl LTs (CysLTs) LTC4, LTD4 and LTE4, are implic...
Atopic asthma is a complex disease process that has a significant social, personal and economic burd...
Leukotrienes (LTs) are potent pro-inflammatory mediators derived from arachidonic acid by the action...
Prostaglandins and leukotrienes are potent eicosanoid lipid mediators derived from phospholipase-rel...
Genetic variants associated with asthma pathogenesis and altered response to drug therapy are discus...
Prostaglandins and leukotrienes are potent eicosanoid lipid mediators derived from phospholipase-rel...
The cysteinyl leukotrienes (cys-LTs), i.e. LTC(4), LTD(4) and LTE(4), trigger contractile and inflam...
The leukotriene receptors (nomenclature as agreed by the NC-IUPHAR subcommittee on Leukotriene Recep...
The leukotriene receptors (nomenclature as agreed by the NC-IUPHAR subcommittee on Leukotriene Recep...
AbstractLeukotrienes (LTs), both LTB4 and the cysteinyl LTs (CysLTs) LTC4, LTD4 and LTE4, are implic...
Cysteinyl-leukotrienes (cysteinyl-LTs), i.e. LTC4, LTD4, and LTE4, trigger contractile and inflammat...
The paper reviews current knowledge on genetic background of action of drugs used in asthma treatmen...
Pharmacogenetics studies of anti-inflammatory medication of asthma have expanded rapidly in recent d...
BACKGROUND: Prostaglandin D2 (PGD2) and cysteinyl leukotrienes (cysLTs) are lipid mediators derived ...
Activation of the prostaglandin D2 receptor (PTGDR) may contribute to pulmonary vasodilation, bronch...
AbstractLeukotrienes (LTs), both LTB4 and the cysteinyl LTs (CysLTs) LTC4, LTD4 and LTE4, are implic...
Atopic asthma is a complex disease process that has a significant social, personal and economic burd...
Leukotrienes (LTs) are potent pro-inflammatory mediators derived from arachidonic acid by the action...
Prostaglandins and leukotrienes are potent eicosanoid lipid mediators derived from phospholipase-rel...
Genetic variants associated with asthma pathogenesis and altered response to drug therapy are discus...
Prostaglandins and leukotrienes are potent eicosanoid lipid mediators derived from phospholipase-rel...
The cysteinyl leukotrienes (cys-LTs), i.e. LTC(4), LTD(4) and LTE(4), trigger contractile and inflam...
The leukotriene receptors (nomenclature as agreed by the NC-IUPHAR subcommittee on Leukotriene Recep...
The leukotriene receptors (nomenclature as agreed by the NC-IUPHAR subcommittee on Leukotriene Recep...
AbstractLeukotrienes (LTs), both LTB4 and the cysteinyl LTs (CysLTs) LTC4, LTD4 and LTE4, are implic...
Cysteinyl-leukotrienes (cysteinyl-LTs), i.e. LTC4, LTD4, and LTE4, trigger contractile and inflammat...
The paper reviews current knowledge on genetic background of action of drugs used in asthma treatmen...
Pharmacogenetics studies of anti-inflammatory medication of asthma have expanded rapidly in recent d...
BACKGROUND: Prostaglandin D2 (PGD2) and cysteinyl leukotrienes (cysLTs) are lipid mediators derived ...
Activation of the prostaglandin D2 receptor (PTGDR) may contribute to pulmonary vasodilation, bronch...
AbstractLeukotrienes (LTs), both LTB4 and the cysteinyl LTs (CysLTs) LTC4, LTD4 and LTE4, are implic...
Atopic asthma is a complex disease process that has a significant social, personal and economic burd...