Evaluation of Marine Agarose Biomaterials for Tissue Engineering Applications.
- Irastorza-Lorenzo, Ainhoa
- Sánchez-Porras, David
- Ortiz-Arrabal, Olimpia
- de Frutos, María José
- Esteban, Emilio
- Fernández, Javier
- Janer, Agustín
- Campos, Antonio
- Campos, Fernando
- Alaminos, Miguel
Publication date
February 2021
DOI Journal
International Journal of Molecular SciencesAbstract
Five agarose types (D1LE, D2LE, LM, MS8 and D5) were evaluated in tissue engineering and compared for the first time using an array of analysis methods. Acellular and cellular constructs were generated from 0.3-3%, and their biomechanical properties, in vivo biocompatibility (as determined by LIVE/DEAD, WST-1 and DNA release, with n = 6 per sample) and in vivo biocompatibility (by hematological and biochemical analyses and histology, with n = 4 animals per agarose type) were analyzed. Results revealed that the biomechanical properties of each hydrogel were related to the agarose concentration (
Add to ORKG