Delayed diagnosis of tuberculosis in persons living with HIV in Eastern Europe : associated factors and effect on mortality-a multicentre prospective cohort study
- Kraef, Christian
- Bentzon, Adrian
- Panteleev, Alexander
- Skrahina, Alena
- Bolokadze, Natalie
- Tetradov, Simona
- Podlasin, Regina
- Karpov, Igor
- Borodulina, Elena
- Denisova, Elena
- Azina, Inga
- Lundgren, Jens
- Johansen, Isik Somuncu
- Mocroft, Amanda
- Podlekareva, Daria
- Kirk, Ole
- Vassilenko, A.
- Klimuk, D.
- Kondratenko, O.
- Zalutskaya, A.
- Bondarenko, V.
- Mitsura, V.
- Kozorez, E.
- Tumash, O.
- Suetnov, O.
- Paduto, D.
- Iljina, V.
- Kummik, T.
- Mshvidobadze, K.
- Lanchava, N.
- Goginashvili, L.
- Mikiashvili, L.
- Bablishvili, Nino
- Rozentale, B.
- Zeltina, I.
- Janushkevich, I.
- Caplinskiene, I.
- Caplinskas, S.
- Kancauskiene, Z.
- Wiercinska-Drapalo, A.
- Thompson, M.
- Kozlowska, J.
- Grezesczuk, A.
- Bura, M.
- Knysz, B.
- Inglot, M.
- Garlicki, A.
- Loster, J.
- uiculescu, D.D.
- Rakhmanova, A.
- Panteleev, O.
- Yakovlev, A.
- Kozlov, A.
- Tyukalova, A.
- Vlasova, Y.
- rofimov, T.T.
- Kyselyova, G.
- Obel, N.
- Gerstoft, J.
- Kronborg, G.
- Payen, M.C.
- abeya, K.K.
- Necsoi, C.
- Dabis, F.
- Tsaranazy, A.
- Cazanave, C.
- Furrer, H.
- Sagette, M.
- Rickenbach, M.
- Sculier, D.
- Calmy, A.
- Cavassini, Matthias
- Bruno, A.
- Bernasconi, E.
- Hoffmann, M.
- Vernazza, P.
- Fehr, J.
- Weber, R.
- Miller, R.
- Vora, N.
- Cooke, G.
- Mullaney, S.
- Wilkins, E.
- George, V.
- Collini, P.
- Dockrell, D.
- Post, F.
- Campbell, L.
- Brum, R.
- Mabonga, E.
- Saigal, P.
- Kegg, S.
- Ainsworth, J.
- Waters, A.
- Dhar, J.
- Ellis, K.
- Girardi, E.
- Rianda, A.
- Galati, V.
- Pinnetti, C.
- Tommasi, C.
- Lapadula, G.
- Di Biagio, A.
- Parisini, A.
- Carbonara, S.
- Angarano, G.
- Purgatorio, M.
- Matteelli, A.
- Apostoli, A.
- Miro, J.M.
- Manzardo, C.
- Ligero, C.
- Gonzalez, J.
- Martinez-Martinez, J.A.
- Sanchez, F.
- Knobel Freud, Hernando
- Salvadó, M.
- Lopez-Colomes, J.L.
- Martínez-Lacasa, X.
- Cuchí, E.
- Falcó, Vicenç
- Curran, Adrian
- Tortola, M.T.
- Ocaña Rivera, Immaculada
- Vidal, R.
- Sambeat, M.A.
- Pomar, Virginia
- Coll, P.
- Pozamczer, D.
- Saumoy, M.
- Alcaide, Fernando
- Caylà, Joan A
- Moreno Camacho, Asunción
- Millet, Joan-Pau
- Orcau, Àngels
- Fina, L.
- Romero, A.
- Roldan, L.L.
- Iribarren, J.A.
- Ibarguren, M.
- Moreno, S.
- González, A.
- Miralles, P.
- Aldámiz-Echevarría, T.
- Losso, M.
- Toibaro, J.
- Gambardella, L.
- Toibaro, J.
- Moreno Macias, L.
- Warley, E.
- Tavella, S.
- Garcia Messina, O.
- Gear, O.
- Laplume, H.
- Marson, C.
- Contarelia, J.
- Michaan, M.
- Scapellato, P.
- Bartoletti, B.
- Palmero, D.
- Elias, C.
- Cortes, C.
- Crabtree, B.
- Mosqueda Gomez, J.L.
- Villanueva, J.A.
- Gonzalez Hernandez, L.A.
- Badial, F.
DOIAbstract
Background: Early diagnosis of tuberculosis (TB) is important to reduce transmission, morbidity and mortality in people living with HIV (PLWH). Methods: PLWH with a diagnosis of TB were enrolled from HIV and TB clinics in Eastern Europe and followed until 24 months. Delayed diagnosis was defined as duration of TB symptoms (cough, weight-loss or fever) for ≥ 1 month before TB diagnosis. Risk factors for delayed TB diagnosis were assessed using multivariable logistic regression. The effect of delayed diagnosis on mortality was assessed using Kaplan-Meier estimates and Cox models. Findings: 480/740 patients (64.9%; 95% CI 61.3-68.3%) experienced a delayed diagnosis. Age ≥ 50 years (vs. < 50 years, aOR = 2.51; 1.18-5.32; p = 0.016), injecting d...
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