Experiments on growing cells can be carried out either in bulk or in confined geometries that constrain the growth of the colony. How should the population trees be sampled in each setup? Are there statistical biases between them? How to quantify natural selection in these trees? These are the main questions we address in this thesis.In a first part, we study the statistical bias between the single-lineage and population levels, which has similarities with fluctuation theorems in stochastic thermodynamics.To do so, we develop a theoretical framework based on lineage histories within population trees, and obtain universal constraints that are exploited in two directions.First, this bias informs on the strength of selection, that quantifies t...
This work presents two problems of biology requiring data analysis and models from statistical mecha...
If growing cells in plants are considered to be composed of increments (ICs) an extended version of ...
Cette thèse porte sur la compréhension des mécanismes de différenciation cellulaire des cellules sou...
Experiments on growing cells can be carried out either in bulk or in confined geometries that constr...
The thesis studies the dynamics of cell populations exhibiting specific types of inter-cellular vari...
Growth pervades all areas of life from single cells to cell populations to tissues. Cell size often ...
Abstract We construct a pathwise formulation of a growing population of cells, based on two differen...
A growing population of cells accumulates genetic mutations. We study stochastic models of this pro...
Population growth is often ignored when quantifying gene expression levels across clonal cell popula...
Cette thèse a pour objectif l’étude de dynamiques de populations cellulaires présentant de la variab...
This work is concerned with growth-fragmentation models, implemented for investigating the growth of...
The problem of the size of a cell population, descendant from a single cell or a small group of cell...
We study the Stochastic Thermodynamics of cell growth and division using a theoretical framework bas...
AbstractPhenotypic cell-to-cell variability or cell population heterogeneity originates from two fun...
This thesis focuses on understanding the mechanisms of stem cell differentiation leading to the prod...
This work presents two problems of biology requiring data analysis and models from statistical mecha...
If growing cells in plants are considered to be composed of increments (ICs) an extended version of ...
Cette thèse porte sur la compréhension des mécanismes de différenciation cellulaire des cellules sou...
Experiments on growing cells can be carried out either in bulk or in confined geometries that constr...
The thesis studies the dynamics of cell populations exhibiting specific types of inter-cellular vari...
Growth pervades all areas of life from single cells to cell populations to tissues. Cell size often ...
Abstract We construct a pathwise formulation of a growing population of cells, based on two differen...
A growing population of cells accumulates genetic mutations. We study stochastic models of this pro...
Population growth is often ignored when quantifying gene expression levels across clonal cell popula...
Cette thèse a pour objectif l’étude de dynamiques de populations cellulaires présentant de la variab...
This work is concerned with growth-fragmentation models, implemented for investigating the growth of...
The problem of the size of a cell population, descendant from a single cell or a small group of cell...
We study the Stochastic Thermodynamics of cell growth and division using a theoretical framework bas...
AbstractPhenotypic cell-to-cell variability or cell population heterogeneity originates from two fun...
This thesis focuses on understanding the mechanisms of stem cell differentiation leading to the prod...
This work presents two problems of biology requiring data analysis and models from statistical mecha...
If growing cells in plants are considered to be composed of increments (ICs) an extended version of ...
Cette thèse porte sur la compréhension des mécanismes de différenciation cellulaire des cellules sou...