A Brief Overview of Triple A Syndrome

Triple A Syndrome, also known as AAA Syndrome, is a rare autosomal recessive disorder caused by any mutation in the AAAS gene on chromosome 12q13, whose main function is to code for the WD-repeat family regulatory protein, ALADIN. It typically occurs as a group of diseases that are characterized by alacrima, Addison\u27s disease, and achalasia. Alacrima can be defined by a decrease in the amount of tears produced while achalasia is nerve damage in the esophagus that can cause difficulty swallowing. Lastly, Addison\u27s disease is the insufficient production of cortisol and aldosterone produced by the adrenal cortex. There is no cure or treatment for triple A syndrome specifically, however, the individual diseases that make up the syndrome are treated as they come