Retinoic acid-induced SoX3 gene expression in NT2/D1 cells is RXR homodimer-independent

Sox3/SOX3 gen je uključen u kontrolu razvića nervnog sistema. Naša prethodna istraživanja su pokazala da tokom neuralne indukcije NT2/D1 ćelija retinoičnom kiselinom (RK) dolazi do promene ekspresije humanog SOX3 gena. Takođe, pokazali smo da su RXR retinoidni receptori glavni posrednici efekta RK na SOX3 ekspresiju, dok su članovi RAR familije receptora isključeni kao njihovi heterodimerni partneri u ovom signalnom putu. Rezultati predstavljeni u ovom radu ukazuju da je aktivacija SOX3 gena retinoičnom kiselinom nezavisna od RXR homodimera. Ova izučavanja ekspresije SOX3 gena su značajna za buduća istraživanja uticaja koji ovaj gen ima na različite aspekte normalnog i patološkog razvića.The Sox3/SOX3 gene is implicated in the control of nervous system development. We previously demon­strated modulation of human SOX3 gene expression during neural induction of NT2/D1 cells by retinoic acid (RA). Also, we accurately verified RXR retinoid receptors as major mediators of the effect of RA on SOX3 expression, and excluded RARs as its heterodimeric partners in RA-SOX3 signaling. Here we present evidence that activation of the SOX3 gene by RA is not RXR homodimer-dependent. The described line of SOX3 gene expression studies is valuable for future investigation of the impact that this gene has multiple aspects of normal and pathological development