The term information is used in different meanings in different fields of study and daily life, causing misunderstanding and confusion. There is a need to clarify what information is and how it relates to knowledge. It is argued that information is meaning represented by physical symbols such as sights, sounds, and words. Knowledge is meaning that resides in a conscious mind. The basic building blocks of information are symbols and meaning, which cannot be reduced to one another. The symbols of information are the physical media of representation and the means of transmission of information. Without the associated meaning, the symbols of information have no significance since meaning is an ascribed and acquired quality and not an inherent p...