This article examines the relations between the knowledge economy and the modes of developing processes between cities and universities for socio-economic development. It starts by considering discourses on the knowledge economy that raise expectations through the circulation of ideas according to their transferability on the market and a desire to place cities on global hierarchies. Such processes do not tend to be subject to interrogation in terms of ‘how’ different parties can work together in ways that either enable or constrain their practice. The article therefore describes work conducted in the Greater Manchester region on collaborations to enhance city development. It is argued that expectations and actual efforts lie in tension. ...