Analysis of auditory function in <i>Diaph2</i> mutant mice.

(A) Mean ABR thresholds of mice carrying the knock-in variant (Diaph2em3Kcl) and (B) the knock-in variant plus a 19bp deletion (Diaph2em2Kcl) at 4 (left), 8 (center) and 14 (right) weeks of age. Male hemizygotes (empty maroon circles) and female homozygotes (filled red circles) have thresholds comparable to female heterozygotes (filled blue diamonds) and male and female wildtypes (squares, female filled green, male empty gold) at all ages. At 14 weeks old the Diaph2em3Kcl female wildtypes have raised high-frequency thresholds compared to the other genotypes, but since there are only three of them and the seven male wildtypes have normal hearing, we suggest that this is not a relevant biological difference. Numbers of each genotype tested are shown on each plot. Error bars show standard deviation.