Infections with influenza A viruses (IAV) cause seasonal epidemics and global pandemics. The majority of these infections remain asymptomatic, especially among children below five years of age. Importantly, this is a time, when immunological imprinting takes place. Whether early-life infections with IAV affect the development of antimicrobial immunity is unknown. Using a preclinical mouse model, we demonstrate here that silent neonatal influenza infections have a remote beneficial impact on the later control of systemic juvenile-onset and adult-onset infections with an unrelated pathogen, Staphylococcus aureus, due to improved pathogen clearance and clinical resolution. Strategic vaccination with a live attenuated IAV vaccine elicited a sim...
It is known since Thomas Francis, Jr. published his first paper on original antigenic sin in 1960 th...
The dynamics and molecular mechanisms underlying vaccine immunity in early childhood remain poorly u...
During the 1918 influenza virus pandemic, which killed approximately 50 million people worldwide, th...
Infections with influenza A viruses (IAV) cause seasonal epidemics and global pandemics. The majorit...
Infections with influenza A viruses (IAV) cause seasonal epidemics and global pandemics. The majorit...
Infections with influenza A viruses (IAV) cause seasonal epidemics and global pandemics. The majori...
Infections with influenza A viruses (IAV) cause seasonal epidemics and global pandemics. The majorit...
Infections with influenza A viruses (IAV) cause seasonal epidemics and global pandemics. The majorit...
Infections with influenza A viruses (IAV) cause seasonal epidemics and global pandemics. The majorit...
Influenza A virus (IAV) is one of the major causative agents of acute respiratory infections in huma...
The immune system of young infants is both quantitatively and qualitatively distinct from that of ad...
Annually influenza causes a global epidemic resulting in 290,000 to 650,000 deaths and extracts a ma...
Respiratory viral infections contribute substantially to global infant losses and disproportionately...
Avian influenza A of the subtype H7N9 has been responsible for almost 1,600 confirmed human infectio...
Influenza during pregnancy can affect the health of offspring in later life, among which neurocognit...
It is known since Thomas Francis, Jr. published his first paper on original antigenic sin in 1960 th...
The dynamics and molecular mechanisms underlying vaccine immunity in early childhood remain poorly u...
During the 1918 influenza virus pandemic, which killed approximately 50 million people worldwide, th...
Infections with influenza A viruses (IAV) cause seasonal epidemics and global pandemics. The majorit...
Infections with influenza A viruses (IAV) cause seasonal epidemics and global pandemics. The majorit...
Infections with influenza A viruses (IAV) cause seasonal epidemics and global pandemics. The majori...
Infections with influenza A viruses (IAV) cause seasonal epidemics and global pandemics. The majorit...
Infections with influenza A viruses (IAV) cause seasonal epidemics and global pandemics. The majorit...
Infections with influenza A viruses (IAV) cause seasonal epidemics and global pandemics. The majorit...
Influenza A virus (IAV) is one of the major causative agents of acute respiratory infections in huma...
The immune system of young infants is both quantitatively and qualitatively distinct from that of ad...
Annually influenza causes a global epidemic resulting in 290,000 to 650,000 deaths and extracts a ma...
Respiratory viral infections contribute substantially to global infant losses and disproportionately...
Avian influenza A of the subtype H7N9 has been responsible for almost 1,600 confirmed human infectio...
Influenza during pregnancy can affect the health of offspring in later life, among which neurocognit...
It is known since Thomas Francis, Jr. published his first paper on original antigenic sin in 1960 th...
The dynamics and molecular mechanisms underlying vaccine immunity in early childhood remain poorly u...
During the 1918 influenza virus pandemic, which killed approximately 50 million people worldwide, th...